Viral Vectors

Viral vector analysis with the Gyrolab immunoassay platform 

Viral vectors are central to the development of modern cell and gene therapies, enabling the delivery of therapeutic genes to target cells. As these therapies move rapidly from discovery to clinical application, reliable analytical methods are essential to characterize vector performance, monitor biological responses, and ensure product quality.

The Gyrolab automated immunoassay platform supports viral vector research and development by enabling highly sensitive and reproducible immunoassays with minimal sample consumption. Its automated microfluidic technology allows researchers to generate consistent data while accelerating assay workflows—supporting both early research and regulated development environments.

Biosimilars

Powering cell and gene therapy breakthroughs 

The Gyrolab platform is designed to support the demanding analytical needs of viral vector development and cell and gene therapy programs. By combining microfluidic technology with fully automated immunoassays, the system enables fast, precise, and scalable analysis of critical biomarkers and therapeutic components.

Researchers benefit from streamlined workflows, reduced assay variability, and the ability to process multiple samples efficiently—helping accelerate progress from discovery to clinical development.

 Key Benefits for viral vector applications 

Nanoliter-scale precision-3

Nanoliter-Scale Precision
Gyrolab microfluidic CDs enable highly controlled nanoliter-scale reactions, reducing reagent consumption while maintaining exceptional assay sensitivity.

 

High reproducibility-3

High Reproducibility
Automated assay execution ensures consistent handling of samples and reagents, minimizing operator-dependent variability and improving data reliability across studies.

Broad dynamic range-2

Broad Dynamic Range
Gyrolab immunoassays support quantification across a wide dynamic range, enabling accurate detection of both low- and high-abundance analytes in complex biological samples.

 

 What researchers are saying 

The Gyrolab platform provided improved sensitivity, precision, and parallelism compared to alternative methods, enabling faster development of assays for complex transgene products."

Principal Scientist | Biopharma company

The Gyrolab system improves assay consistency and throughput for therapeutic research compared to plate-based ELISA.

Principal Scientist | Biopharma company

The main benefits of the Gyrolab® Anti-AAVX Kit are reduced method development and reduced use of precious capsid.

 

The advantage of the Gyrolab® Anti-AAVX Kit is that it’s plug-and-play so you can use your specific serotype and drug. You do not have to label the drug, and it is much easier to compare the immunogenicity of a generic serotype capsid to the drug.

 Bayer logo

Yvonne Katterle

Senior Scientific Lead Bioanalytics LBA | Bayer, Germany

Case study 1

A gene therapy company improved AAV8 titer testing using the Gyrolab AAVX Titer Kit, achieving faster results with enhanced precision and reproducibility. The kit provided a broader dynamic range and required less sample volume than ELISA, streamlining workflows and supporting efficient process development for advanced therapeutic programs.

Comparison Progen ELISA vs Gyrolab AAV Capsid Titer​

Case study 2 

Gyrolab was used to overcome challenges in transgene quantification and immunogenicity assays. Compared to other platforms, Gyrolab demonstrated superior parallelism and robust results, enabling the development of assays fit for purpose in cell and gene therapy.  

Platform comparison MSD versus Gyrolab platform parallelism
Platform comparisons MSD versus Gyrolab platform sensitivity and precision

Gyrolab vs ELISA for cell and gene therapy research 

Time to results

Time to results

Results in just over an hour, compared to several hours or overnight with ELISA.

Hands-on time

Hands-on time

Automated processing reduces manual pipetting and intervention.

Dynamic range

Dynamic range

Fewer dilutions are needed to bring samples into range.

Matrix tolerance

Matrix tolerance

The flow-through format reduces background in complex matrices such as serum.

Sample volume

Sample volume

Nanoliter-scale assays require significantly smaller sample volumes than plate-based methods.

Throughput and runs required

Throughput and runs required

Higher pass rates and faster runtimes reduce repeat burden keeping your project timelines on track.

Further reading

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