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Peptide nucleic acids (PNAs) are a class of modified peptides with a repetitive polypeptide-like backbone of N-(2-aminoethyl) glycine to which nucleic acid bases are attached with spacing analogous to the distances in native nucleic acid structures. Their synthetic structure conveys properties that are advantageous such as higher binding affinity and specificity of shorter probes to DNA sequences, increased stability, and resistance to degradation in biological fluids. These properties have made PNA analogs uniquely useful in research and clinical applications, from fluorescent in-situ hybridization probes (FISH) to gene silencing tools, both in early discovery and for anti-sense therapeutic development.
Synthesis of PNAs can be accomplished with conventional solid-phase peptide synthesis protocols using N-protected PNA monomers. Peptide synthesizers from Gyros Protein Technologies are highly effective tools in the production of PNAs, as their flexibility allows for the use of not only natural amino acids, but also a myriad of other building blocks, which can be added to the sequence with carefully designed programs.
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Learn about the synthesis of peptide-PNA sequence, highlighting the differences between manual and automated approaches, using Symphony® X peptide synthesizer from Gyros Protein Technologies, and the challenges faced during this process.
Learn how a model PNA sequence was successfully synthesized alone, and as part of a PNA-peptide conjugate on the Prelude peptide synthesizer in a single synthesis at the 10 μmol scale.