Peptoids belong to a class of molecules known as peptidomimetics, the molecules that mimic the biologic interactions of peptides. Peptoids are structurally similar to peptides, with a carbon-nitrogen backbone mimicking a peptide chain, but the functional side chains are attached to the amine nitrogen rather than to the α-carbon. This rearrangement confers greater stability against proteolysis, and reduced immunogenicity, making these molecules highly useful as drug candidates with an improved pharmacokinetic profile and higher membrane permeability.  

Since therapeutics for neurological diseases such as Alzheimer’s disease require blood-brain permeability, peptoids have been evaluated for use as inhibitors of β-amyloid aggregation and for signaling pathway modulation to interrupt disease mechanisms. The relative ease of synthesis of peptoids along with their stability also makes these molecules useful for synthesis and screening of capture molecules for biomarkers.  

The high flexibility of peptide synthesizers from Gyros Protein Technologies provides the right tools for the synthesis of these peptoids, since it is possible to include different types of monomers and program a wide range of synthetic protocols. 

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Synthesis of [des-Arg7]-Dyn A (1-9)-NH2 peptoid hybrid

Learn about synthesis of a complex peptoid on the Prelude X using a monomer method with heating for faster reaction times.

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