Rapid and robust immunoassays

Biomarker analysis provides prognostic, predictive, pharmacodynamic (PD), safety, or surrogate endpoint information for therapeutic interventions. 

Precise and robust fit-for-purpose biomarker immunoassay methods are needed to support preclinical and clinical biotherapeutic development, with single biomarker assay development typically occurring prior to preclinical studies of a drug candidate. Gyrolab® immunoassays provide fully automated, robust assay performance with high precision, a wide dynamic range, and straightforward custom assay development, supporting biomarker analysis in regulated environments. 

biomarker-monitoring &-pharmacodynamics

The recent introduction of the Gyrolab Bioaffy™ 4000 CD expands Gyrolab assay sensitivity for a more powerful solution to biomarker analysis down to low pg/mL levels.

  • Robust and reliable biomarker quantification
    Reproducible data across operators and instruments and over long time periods
    Straightforward validation for regulated studies
    Software designed for 21 CFR Part 11 compliance
  • Fully automated, rapid time to results
    About one hour run times with automated assay workflow 
    Limit hands-on and in-lab time  
  • High sensitivity & wide dynamic range
    Low pg/mL sensitivity
    3-4 logs dynamic range 
  • Open platform for flexible assay development
    Flexible assay development for your immunoassay design and reagents
    Gyrolab assay protocols available for cytokine analysis
  • Biomarker assays run precisely with Gyroplex® panels
    Independent reactions with high sensitivity and quality results 

Biomarker quantification using Gyrolab platform positively impacts productivity in the development of therapeutics.

Gyrolab assay protocols are available for the cytokine and other biomarkers below:

Non-human primate

NHP IL-13 Human/NHP IL-2
NHP IL-8 Human/NHP IL-4
Human/NHP IFN-gamma Human/NHP IL-6

 

Human

Human GLP-1 Active Human IL-13 Human TNF-alpha
Human GLP-1 Total Human IL-2 Human VEGF
Human IFN-gamma Human IL-22 Human/NHP IFN-gamma
Human IL-1 beta Human IL-4 Human/NHP IL-2
Human IL-10 Human IL-6 Human/NHP IL-4
Human IL-12p70 Human IL-8 Human/NHP IL-6

 

Mouse

Mouse Erythropoietin (EPO)

Mouse IL-17A

Mouse TNF-alpha

Mouse IFN-gamma

Mouse IL-22

Mouse IL-17A

Mouse IL-10

Mouse IL-4

Mouse IL-6

Mouse TNF-alpha

 

 

 

Rat

Rat Clusterin

Rat Erythropoietin (EPO)

Rat KIM-1

 

Svar Flexi Solutions (Human Analytes)

Calprotectin

Complement C4d

TCC

 

 

Want to learn more? Speak to our scientists about your application.