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Synthetic foldamers are artificial molecules including peptides, nucleic acids, and polysaccharides, whose monomer sequence enables them to spontaneously fold into a defined three-dimensional conformation that is stable in biological environments. Other characteristics that are desirable for foldamers as therapeutics includes resistance against proteases for long serum half-lives and tighter protein-protein interactions – e.g., for high affinity receptor binding.
These non-natural molecules mimic the shape of naturally occurring macromolecular structures and are used in basic research for disease mechanisms, as potential therapeutics, and for basic research studying the relationship between sequence and formation of tertiary structures such as beta sheets and alpha helices in molecular design.
Solid-phase peptide synthesizers from Gyros Protein Technologies provide the flexibility needed for foldamer synthesis.
A Webinar on 18th of November will be presented describing the work of Celine Douat on foldamer synthesis using PurePep® Chorus®. Check back for more information.