Synthetic foldamers are artificial molecules including peptides, nucleic acids, and polysaccharides, whose monomer sequence enables them to spontaneously fold into a defined three-dimensional conformation that is stable in biological environments. Other characteristics that are desirable for foldamers as therapeutics includes resistance against proteases for long serum half-lives and tighter protein-protein interactions – e.g., for high affinity receptor binding.  

These non-natural molecules mimic the shape of naturally occurring macromolecular structures and are used in basic research for disease mechanisms, as potential therapeutics, and for basic research studying the relationship between sequence and formation of tertiary structures such as beta sheets and alpha helices in molecular design.  

Solid-phase peptide synthesizers from Gyros Protein Technologies provide the flexibility needed for foldamer synthesis.  

  • Design sequences comprised of any kind of (soluble) monomer 
  • Elongate the sequence with flexible synthesis programs  

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Automation of Solid-Phase Aromatic Foldamer Synthesis

Dr Céline Douat, University of Munich (LMU) - Germany describes efficient and reliable coupling methodologies which remain very remote from conventional peptide coupling approaches on the solid phase. The versatility of the PurePep Chorus instrument will be highlighted and with a special focus on how a peptide synthesizer can be diverted from its initial application to meet the needs of a growing field of research: i.e. foldamer chemistry.

Dr. Céline Douat, PhD, Scientific Co-Worker,
Chair of Chemical Biology (Group of Prof. Ivan Huc),
Dept. of Pharmacy, University of Munich (LMU) - Germany.



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