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    Pharmacokinetic (PK) studies

Pharmacokinetic (PK) studies

Faster PK data, less sample use

Pharmacokinetic (PK) and toxicokinetic (TK) bioanalysis puts constant pressure on time, sample volume, and reproducibility. Studies scale quickly, sample numbers grow, and timelines rarely move. Gyrolab streamlines PK and TK workflows with automated nanoliter-scale immunoassays, providing rapid, reliable results while minimizing manual labor and variability across runs. From early preclinical studies through clinical development, your lab moves faster without losing data quality.

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PK

Why PK labs choose Gyrolab

Shorter turnaround times
Generate PK results in just over one hour instead of waiting most of a day or overnight.

Consistent, reproducible data
Automated workflows reduce operator-dependent variation across batches, studies, and sites.

Higher throughput with less hands-on time
One operator can process hundreds of data points, freeing up time for other important tasks.

 

Wide dynamic range
Fewer dilutions are needed, even when concentrations vary significantly across samples.

Low sample volume requirements
Nanoliter-scale assays are well-suited for rodent studies, limited sample availability, and longitudinal sampling.

PK workflows supported by Gyrolab

 Gyrolab is used across PK and TK studies where speed, efficiency, and reproducibility are critical, including: 

  • Preclinical PK studies

  • Clinical PK, Phase I through Phase III
  • Drug exposure and dose-response profiling
  • Bioanalytical method development and validation
  • Batch comparability studies
  • Data generation supporting IND and CTA submissions

 

How Gyrolab improves PK workflows

Gyrolab automates PK and TK immunoassays at nanoliter-scale, reducing manual handling and shortening time to results. Samples are processed in a microfluidic disc, with a flow-through format that supports a broad dynamic range and helps limit matrix-related variability.

Fewer dilution steps mean many samples fall directly within range, even when concentrations vary across a study. Automated processing ensures consistent handling of every data point, improving reproducibility across runs, operators, and sites, while freeing up time for other work.



Gyrolab vs ELISA for PK studies

Time to results

Time to results

Results in just over an hour, compared to several hours or overnight with ELISA.

Hands-on time

Hands-on time

Automated processing reduces manual pipetting and intervention.

Dynamic range

Dynamic range

Fewer dilutions are needed to bring samples into range.

Matrix tolerance

Matrix tolerance

The flow-through format reduces background in complex matrices such as serum.

Sample volume

Sample volume

Nanoliter-scale assays require significantly smaller sample volumes than plate-based methods.

Throughput and runs required

Throughput and runs required

Higher pass rates and faster runtimes reduce repeat burden keeping your project timelines on track.

Further reading

Validation and data confidence

Gyrolab is used in bioanalytical preclinical and clinical environments where data integrity, traceability, and reproducibility matter. Automated workflows reduce operator-dependent variation, while software support provides audit trails, controlled user access, and structured data handling to support compliance with GLP/GMP expectations.

Assays can be transferred between systems and sites with reproducible results, supporting long-term studies and regulatory submissions without added complexity.

 

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Ready to improve your immunoassay workflow?

Discuss your PK studies with a Gyrolab specialist and explore how automation could support your timelines and data needs.