Gyrolab for NAMs and the 3Rs | Low-Volume Bioanalysis

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NAMs & the 3Rs

Enable low-volume bioanalysis for next-generation drug development

New Approach Methodologies (NAMs) are changing how biopharmaceutical teams evaluate safety, efficacy, and translational biology. But many NAM workflows share a practical limitation: they generate very small sample volumes.

Gyrolab^® automated immunoassays help scientists generate high-quality PK, ADA, and biomarker data from minimal sample volumes, supporting more efficient preclinical and translational workflows aligned with the 3Rs: Reduce, Refine, and Replace.

Supporting NAM-enabled bioanalysis

Alternative models such as organoids, organ-on-chip systems, microphysiological systems, and microsampling studies can provide powerful biological insight. To make these models useful in drug development, teams need analytical methods that can measure critical readouts from very limited material.

Gyrolab nanoliter-scale immunoassay technology combines automated workflows, low sample consumption, broad dynamic range, and reproducible data generation - helping teams move from limited sample to confident decision-making.

How Gyrolab supports the 3Rs

Reduce animal use

Low sample volume requirements help researchers generate more data from each available sample. In preclinical studies, this can support reduced animal numbers, fewer repeat experiments, and more efficient study designs.

Gyrolab helps by:

Using very small sample volumes
Enabling more measurements from limited samples
Reducing repeat testing through broad dynamic range and reproducible performance

Refine sampling strategies

When studies require animal samples, smaller volume requirements can support less invasive sampling approaches and improved study design flexibility.

Gyrolab helps by:

Supporting microsampling-compatible workflows
Reducing sample demand compared to traditional plate-based assays
Automating immunoassays to minimize hands-on variability

Enable replacement models

Many replacement-oriented NAMs produce small-volume outputs that can be difficult to analyze using conventional methods. Gyrolab can help make these models more analytically viable by enabling sensitive immunoassay readouts from scarce samples.

Gyrolab helps by supporting readouts from:

Organoids
Organ-on-chip systems
Microphysiological systems
Small-volume translational models

Why low-volume bioanalysis matters

Many NAM workflows are limited not by the biology but by the ability to measure meaningful analytes from small samples.

Traditional immunoassays can require larger sample volumes, more manual steps, and more repeat testing. Gyrolab technology helps address these bottlenecks by automating nanoliter-scale immunoassays and reducing sample and reagent consumption.