Maximum flexibility for research, optimization and production

With Ultra PurePep® Pathway

  • Ultra PurePep® Pathway "inside"- Pure reliability
  • Fully independent channels
  • Infrared heating
  • Real-time UV monitoring
  • Preactivation
  • Special reagent additions
  • Automated cleavage
  • Designed for 21 CFR part 11 compliance


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Ultra PurePep® Pathway "inside"- Pure reliability

The proprietary ultra PurePep Pathway is enhanced with a dedicated microfluidic matrix valve block pathway for each reaction vessel resulting in pure peptides. Nitrogen and vacuum move all fluids through the system, the membranes are resistant to harsh chemicals, there is zero dead volumes, no cross-contamination, and best-in-class performance that lasts for years. Other systems use off-the-shelf valves that leak or corrode, result in cross-contamination, and quickly fail when exposed to harsh peptide synthesis chemicals. With the ultra PurePep Pathway inside Symphony® X, all fluid deliveries are verified via optical sensors and you have reliable peptide purity every time.

Fully independent channels

Symphony X is the world’s first peptide synthesizer with fully independent channels. This means you can run different sequences, scales and protocols on multiple reactors all at the same time. Start, Stop or Pause reactors whenever you wish! It’s like having 24 synthesizers in one.

Infared (IR) heating

Efficient heating, reaching set temperature in minimal time. It is also fully-compatible with vortex mixing, so you can be sure you have an even temperature profile. Other heating systems use nitrogen mixing, which may result in hot and cold spots and effect the consistency of your chemistry.

Real-time UV monitoring

Minimize trial-and-error when synthesizing difficult peptides using the Intellisynth® real-time UV monitoring on the Symphony X instrument. What makes our UV monitoring different? Other systems just monitor the waste stream. We monitor your reaction solution while it’s mixing – that’s why we’re the only ones who can control the deprotection reaction times, not just the number of repetitions. Real-time UV monitoring ensures that reactions are completed efficiently and no excess reagent is wasted.


Now you can preactivate on multiple reactors in parallel. Perfect for sterically hindered amino acid additions! Optimize your DIC/HOBt chemistry on Symphony X and go straight to scale-up.

Special reagent additions

At last! Add expensive special reagents to any reactor without priming or wasting a drop using Single-Shot™ deliveries! Save money with no manual intervention required! Symphony X comes with up to 40 amino acid positions to accommodate any chemistry.

Automated cleavage

Symphony X includes the ability to do automated, fully customizable cleavage without the need for an additional module. Choose to cleave immediately (Fmoc only), at the end of a synthesis, or at a specified date and time. Cleaved peptides are collected in convenient 50 mL centrifuge vials. All Protein Technologies’ synthesizers are built with robust TFA-resistant materials, so you can cleave for years on the instruments without worry. Not interested in cleavage? You have the flexibility to use the Symphony X collection positions as additional amino acid positions.


Installation qualification and operation qualification (IQ/OQ) support services verify and document that your instrument is supplied, installed, and operating according to GPT specifications, and may be required for operating under cGMP conditions. GPT-certified field service engineers inspect critical components, ensure that your systems function properly and reproducibly during automated synthesis operations, and provide documentation to help you meet regulatory requirements.

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Number of reaction vessels
24 (12 with pre-activation option), no resin loader required
Synthesis scale range
0.005 – 24 mmol (up to ~2 g of resin per RV)
Reaction vessel volume
Plastic, disposable:10 mL, 45 mL, Borosilicate glass: 10 mL, 40 mL
Number of solvent positions/sizes
1 primary solvent position, 20 L capacity
7 user-defined solvent positions, 0.5 L - 4 L capacities, larger capacity vessels available
Number of amino acid positions
Up to 40 amino acid positions
10 mL, 120 mL and 400 mL bottles
Chemistries supported
Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA
Activation In situ HBTU, HATU, HCTU, TBTU, PyBOP, PyOxim, DIC/OxymaPure, DIC/HOBt, DIC/Oxyma-B and others
Throughput User defined
Fluid measurement technique
Fixed loop measurement with optical sensors
Fluid transfer method
Positive pressure with nitrogen; top down delivery
Agitation method
Nitrogen bubbling and/or vortex mixing can be adjustable and programmable
Automated on-board cleavage, separate fluid path and vent
Waste container
One 20 L container with over-flow sensor
Control interface
Proprietary Symphony X control software, internal CPU and touchscreen monitor included
Real-time log of each instrument function, print to file or printer. Printable .pdf file for each method created.
Start-up kit
40 pre-packed AA bottles (20 natural amino acids; 5 mmol and 20 mmol scales), Reaction Vessels (Prelude disposable RVs, 30 pack of 10 mL and 30 pack of 45 mL RVs), Rink Amide Resin (0.1 mmol scale), Fmoc-Gly Wang Resin (0.1 mmolscale), HCTU (100 g), Activator Sample kit (5g each of K-Oxyma, PyOxim, OxymaPure and HDMA). Shipments to the USA also include 20% Piperidine/DMF and 0.4M N-Methylmorpholine/DMF (0.9 L each) reagents.  (Cat#: SYMX-STARTKIT)
115 V/60 Hz or 230 V/50 Hz
Dimensions (W x D x H)
45” x 29” x 66” (114 cm x 74 cm x 168 cm)
Approximately 550 lbs. (250 kg)
One year, parts and labor.
OPTIONAL - Heating
Infrared (IR) heating (Cat#: SYMX-IR-OPT)
OPTIONAL - UV Monitoring
Intellisynth Real-time UV Monitoring and feedback control system and software (Cat#: SYMX UV OPT)
OPTIONAL - Software
E-mail-Text Message Status Reporting (Cat#: SYMX-TXT-EML-RP)


PurePep Reagents

As of March 31, 2024, Gyros Protein Technologies has discontinued many of our peptide research reagents. This includes:
  • Cleavage kits
  • Bulk FMOC amino acids
  • Solvents
  • Pre-packed Tribute vials
  • Pseudoproline dipeptides
  • Pre-packed PS3 vials
  • Resins
  • Two sizes of pre-packed bottles for PurePep Chorus, Symphony, & Prelude X
Instrument starter kits and two sizes of pre-packed bottles for PurePep Chorus, Symphony, and Prelude X remain available.    

Your peptide synthesis needs are important to us. If you would like custom packaging or other special handling conditions please send us your request here



Looking for technical documentation and references?

Find more technical documentation on our products as well as scientific references in our resource library. Learn about the ways our customers are using our products in research applications and peptide development.


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