NEW Gyrolab® Generic Rodent ADA Kit Reagents measure anti-drug antibodies as circulating immune complexes of human IgG in complex with rodent anti-human IgG on Gyrolab systems.

  • Gyrolab Generic Rodent ADA Kit Reagents are ordered as a bundle that contains capture and detection reagents with sufficient volume for approximately 480 data points, sample dilution buffer, and wash buffer. 
  • Gyrolab Bioaffy 1000 CDs* are purchased separately; all bundle components can also be ordered separately.

The generic nature of the Gyrolab Generic Rodent ADA Kit Reagents favors its use in early preclinical studies in mice or rats for ADA screening of therapeutic antibody candidates or for investigation of unexpected PK clearance profiles, safety, or efficacy issues caused by the formation of immune complexes. A generic assay eliminates the need for assay optimization across molecules and rodent species thereby streamlining preclinical development.

*Kit Reagents also provide assay flexibility for use with other Gyrolab Bioaffy CD types (requiring assay development).

GRAPH: A typical example of a serially diluted Mouse Positive Control in Rexxip H detected using the Gyrolab Generic Rodent ADA Kit Reagents and the Gyrolab Bioaffy 1000 CD.

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Gyrolab® Generic Rodent ADA Kit Reagents Bundle

Gyrolab® Generic Rodent ADA Kit Reagents Bundle contains ready-to-use capture and detect reagents, Rexxip H sample dilution buffer, and Gyrolab Assay Wash Buffer Duo with sufficient volumes to generate approximately 480 data points (5 CDs). CDs not included. P0021054

Gyrolab® Generic Rodent ADA Kit Reagents

Gyrolab® Generic Rodent ADA Kit Reagents contains all reagents as ready-to-use solutions with sufficient volume for approximately 480 data points. P0021053

Gyrolab Bioaffy 1000 CD

1000 nL sample volume, 96 data points. Provides extended sensitivity for e.g., PK or biomarker assays. P0004253

Gyrolab Generic Mouse ADA Positive Control

Mouse ADA Positive Control, 50,000 ng/mL, 50 μL. P0021055

Rexxip H

25 mL, 1 x standard formulation, agents to neutralize heterophilic antibodies. For samples containing heterophilic antibodies (e.g., human or cyno samples) and where the assay format (Ab/Ab) could cause false positives. P0004822

Gyrolab Accessories Bundle

Includes: 96-well plate, 0.2 mL skirted PCR plates (x3), Microplate Foils (x3), Wash Station Solution 2: Gyrolab Wash Buffer pH 11(x1). All can be ordered separately. P0020863

Gyrolab Assay Wash Buffer Duo

Includes Wash Buffer 1 and Wash Buffer 2. P0020669

To accelerate assay development, Gyrolab Assay Protocols are available for mAbs and biosimilar therapeutics. 

 

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