Transform the performance and productivity of bioprocessing immunoassays: miniaturize, automate, and analyze faster.

Immunoassays are an essential analysis tool used throughout biotherapeutic development and manufacturing to evaluate titer and process impurities. The Gyrolab platform offer key advantages for titer analysis in applications such as cell line development. The robust, nanoliter-scale automated platform provides high throughput and rapid assay results to support data-driven decision making.

In addition, process-related impurity concentrations are highly regulated in the manufacture of biologic drugs because of their immunogenic potential. Bioanalytical methods to detect and measure process related impurities must be developed carefully to characterize heterogeneous mixtures of host cell proteins (HCPs) present in samples, or the copurification of culture or process impurities such as protein A together with the biotherapeutic.

Gyrolab^®reagents

Gyrolab ready-to-use kits and solutions have been optimized for best assay performance and include everything needed to perform miniaturized immunoassays in a plug-and-play format on all Gyrolab systems.

CHO HCP 3G Solution for Gyrolab

Ready-to-use Gyrolab solution for the detection of CHO host cell protein (HCP) impurities.

E.Coli HCP 2G Solution for Gyrolab

Ready-to-use Gyrolab solution for the detection of E.coli host cell protein (HCP) impurities.

Gyrolab PLBL2 Kit

Gyrolab PLBL2 Kit for detection of Hamster phospholipase B-like 2 (PLBL2), a prevalent and challenging residual Host Cell Protein (HCP).

Gyrolab Protein A Kit

Ready-to-use Gyrolab Kit for detection of Cytiva's MabSelect SuRe^™ ligands in antibody preparations after Protein A purification processes.

Sf9 HCP 3G Solution for Gyrolab^®

Ready-to-use Gyrolab Solution for detection of HCPs from Sf9 insect cells.

Gyrolab HEK293 HCP Kits

Ready to use Gyrolab kits for detection of HCPs from HEK293 cells. Process
specific kits available for detecting HCPs in samples from cell lysate (Type CL) or supernatant (Type SN).

Gyrolab huIgG Kit – High Titer

Ready-to-use Gyrolab kit for rapid quantification of human mAb titers in supernatants up to 1 mg/mL.

Gyrolab HCP labeling packages

Gyros Protein Technologies provides labeling of process-specific HCP reagents and assay optimization on Gyrolab systems. We ensure a reliable and reproducible labeling process of critical reagents, either customer-proprietary process-specific HCP reagents or generic HCP reagents from Biogenes.

Gyrolab huIgG Kit - Low Titer

Ready-to-use Gyrolab kit for rapid quantification of human mAb in supernatants in levels from 1 ng/mL to 20 µg/mL.

Gyrolab^® Systems

Gyrolab Systems are reliable and precise walk-away automated immunoassay systems that give you and your team the agility to develop immunoassays more quickly with minimal hands-on time, accelerating every phase of biotherapeutic product development.

The systems are a powerful tool for increasing productivity, generating reproducible data, and making data-driven decisions faster.

Gyrolab xPlore^™

Generates up to 112 high-quality data points within an hour
Offers an easy transition to Gyrolab xPand as your needs grow

Gyrolab xPand

Generates up to 560 high-quality data points within 5 hours
Cooling of samples and reagents

Customized assay services

Eliminate workflow bottlenecks by letting our highly experienced scientists optimize your assays for the Gyrolab® platform.

Gyrolab assay protocols

Accelerate development of commonly used immunoassays, with ready-to-use and robust Gyrolab assay protocols.

Find assay protocols

Related content

Immunoassays to maximize productivity in bioprocess development

High productivity requires efficient analytical testing, including measurement of product titer and process impurities, but commonly used methods such as ELISA or HPLC are time-consuming and can create bottlenecks in critical workflows. Here we illustrate how Gyrolab immunoassays meet the critical requirements for immunoassays used in the process development of an IgG therapeutic antibody, from initial cell culture to final purified product.

Miniaturizing immunoassays for improved performance

With conventional immunoassay formats like ELISA, assay development takes time and requires a lot of reagents. The assay has long incubation times, limited experimental flexibility, limited dynamic range and matrix compatibility. This article presents three case studies that demonstrate how the Gyrolab immunoassay platform enables rapid and flexible assay development, improved assay performance and significantly reduced sample/reagent consumption compared to ELISA.

Case Study: Host-cell protein analysis to support downstream process development

A High-Throughput Platform with Automated Sample Preparation

Petrovic S, et.al.Sanofi scientists present the successful implementation of the Gyrolab immunoassay system as a reliable platform for high-throughput HCP analysis, in combination with a robotic liquid handling system. The results were comparable to their gold-standard ELISA method.

Nonoliter-scale Immunoassays for time critical workflows

Sanofi has successfully developed and implemented the Gyrolab® xP workstation and Gyrolab CHO-HCP E3G assay. These cutting-edge technologies ensure reliable and highly sensitive detection of HCP, while supporting accelerated bioprocess development. Moreover, to further increase productivity and reduce dilution errors, manual sample preparation steps were automated using the Bravo platform (Agilent).

Ask an expert how Gyrolab platform can help maximize immunoassay speed and quality in biotherapeutic development.

Ask an expert