Replacement Instrument – PurePep® Sonata®+

Scale Up Peptide Synthesizer

With PurePep® Pathway

  • PurePep® Pathway “Inside” – Pure reliability
  • Multiple mixing modes
  • Solvent and reagent positions
  • Simple software
PurePep Pathway “Inside”
The design power of the proprietary PurePep Pathway (valve block system) results in zero dead volumes, no cross-contamination, and worry-free performance that lasts for years. Other systems use off-the-shelf valves that leak, cross-contaminate, and quickly fail when exposed to harsh peptide synthesis chemicals. With the trusted PurePep Pathway inside Sonata/Sonata XT, you have reliable peptide purity every time.
Multiple mixing modes
Sonata has chemically inert, optimized channels allowing high solution transfer rates (> 400 mL/min) of any solvent. All reactions occur in an inert environment to minimize side reactions. Multiple mixing modes including sparging, recirculation and mechanical agitation which can be combined to maximize reaction efficiency. Several fluid-filling methods can be selected to optimize performance.
Solvent and reagent positions
Seven solvent ports and twenty reagent ports allow easy customization for any synthesis protocol. Two volumetric vessels allow precise aliquots of all solvents/reagents to be delivered. To minimize disposal costs, two waste ports allow waste streams to be separated. A collection port can be implemented for cleavage product or valuable reagent recovery for maximum versatility.
Simple software
Versatile, easy to use Windows®-based software allows the experienced chemist or novice operator complete control of all aspects of synthesis. Complete documentation of all operations occurs once synthesis is initiated.


Installation qualification and operation qualification (IQ/OQ) support services verify and document that your instrument is supplied, installed, and operating according to GPT specifications, and may be required for operating under cGMP conditions. GPT-certified field service engineers inspect critical components, ensure that your systems function properly and reproducibly during automated synthesis operations, and provide documentation to help you meet regulatory requirements. Read more


Number of reaction vessels
Synthesis scale range
0.05 mmol to 100 mmol (200 mmol on Sonata XT)
Reaction vessel volume
Glass: 200 mL, 500 mL, 1.2 L, 2 L, 3.2 L, 4.2 L
Custom sizes available
Number of solvent positions/sizes
1 primary solvent, 1 L – 200 L capacity
6 user-defined solvent positions, 0.5 - 8 L capacities, larger capacity vessels available
Number of amino acid positions
20 amino acid / reagent positions, 250 mL capacity (500 mL or 1 L on Sonata XT)
Chemistries supported
Fmoc, t-Boc, organic, peptoid, combinatorial, others
User defined
Fluid measurement technique
Fixed volumetric vessels with optical sensors, 10, 25, 50, 75, 100 mL sizes, other optional
Timed delivery
Fluid transfer method
Positive pressure with nitrogen for solvents and reagents
Dedicated pump for primary solvent
Agitation method
Nitrogen bubbling (adjustable), variable vortexing, recirculation
-Alone or in combination
Automatic, programmable (for Fmoc chemistry only)
Waste container
20 L container with overflow sensor
200 L option available
Control interface
Proprietary Sonata control software. The system is used in a GMP environment.

Menu-driven. Stand-alone computer, flat panel monitor and printer included.
Real-time log of each instrument function. Print to file, screen or printer.
115 V/60 Hz or 230 V/50 Hz
Dimensions (W x D x H)
35" x 23" x 63.5" (89 cm x 58 cm x 161 cm)
Approximately 400 lbs. (182 kg)
One year, parts and labor

PurePep Reagents



Coupling Agents


Your peptide synthesis needs are important to us. If you would like custom packaging, other special handling conditions, or a quote please send us your request here


All instrument accessories and spare parts are available to order in our online shop, you can open the Sonata/Sonata X accessories here