Peptide Synthesis Resources

Find technical documentation on our products as well as scientific references. Learn about the ways our customers are using our products in research applications and peptide development.

Optimizing synthesis of SARS-CoV-2 peptides for epitope analysis


The speed and flexibility of peptide synthesis is a major advantage over protein-based biologics when handling rapidly evolving conditions, such as therapeutics related to SARS-CoV-2 vaccine development and neoantigen peptide-based vaccines. Download the white paper to learn more on how to optimize the synthesis of multiple peptides with therapeutic potential, with a real-world example of optimizing SARS-CoV-2 peptides for epitope analysis.

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Meeting the challenge of synthesizing complex therapeutic peptides


While many therapeutic peptides are variants of natural peptides, advances in #SolidPhasePeptideSynthesis has enabled the design of more refined molecules that are more readily able to penetrate the cell membrane, more stable, and resistant to degradation. The demand for increasingly complex therapeutic peptides has resulted in the development of robust, efficient, and rapid synthesis protocols and instrumentation that can meet the demands of GxP and regulatory authorities. Download the white paper to read more about synthesizing complex therapeutic peptides.

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Comparison of Different Heating Protocols for the Cyclization of Melanotan II on the Prelude X

Heat-assisted synthesis has been shown to reduce the time necessary to produce high-purity linear peptides, and its application to the synthesis of cyclic peptides may provide similar advantages.


Multivariable Individual Heating Conditions Tested in Parallel Provide Rapid Process Optimization on Prelude X

The application of heat represents a useful tool to optimize the production of challenging synthetic peptides, and a new technology, induction heating, has been introduced on the Prelude X.


Parallel Synthesis and Rapid Heating on the Prelude X

Building upon the strength of the original Prelude platform, the Prelude X adds heating, oscillation shaking, and UV monitoring to deliver uncompromised speed, yield, reagent savings, and flexibility, creating the most complete peptide synthesis solution available.


Rapid synthesis of difficult peptide sequences using parallel heating and UV monitoring on the Prelude® X

Peptides have been recognized as highly selective and generally well tolerated drug candidates, increasing the demand for rapid access to different peptide sequences in order to accelerate the evaluation of potential therapeutics.


Simultaneous optimization of the synthesis of difficult peptides in the Prelude® X automated synthesizer using a novel reagent combination

The coupling reagent COMU has been demonstrated to be highly efficient in the synthesis of a variety of peptides.


Reduced Cycle Times & Solvent Consumption of 65-74ACP on Symphony X

New and optimized methods for rapid peptide synthesis, combined with instruments capable of parallel synthesis enable the production of peptide libraries with high throughput.


Ziconotide: high-throughput process optimization using automated parallel synthesis

The Symphony X™ multiple peptide synthesizer offers the most flexibility and independent protocols of any instrument on the market, making it an ideal platform for high-throughput process development.


Fast and efficient automated, on-resin synthesis of disulfide-bridged type-II diabetes-related peptide amylin

Type-II diabetes, caused by chronic insulin resistance and a progressive decline in pancreatic ?-cell function, affects over 150 million people worldwide [1]. The 37-mer human islet amyloid polypeptide (IAPP) (Figure 1) or amylin, is a major contributor to the amyloid deposits found in the pancreases of patients with typeII diabetes [2,3].


Investigating improved purity, yields of Alzheimer’s disease related peptide: human beta-amyloid (1-42)

Human ?-amyloid (1-42) (Figure 1) is a major component of the plaque deposits found in the brains of patients with Alzheimer’s disease (AD) [1]. b-amyloid is in constant demand for the continued research into the pathology, diagnostic tools, and potential therapeutics for AD.


Efficient synthesis of 84-mer human Parathyroid hormone for the study of osteoporosis and hypoparathyroidism

Human parathyroid hormone (1-84) (PTH) (Figure 1) is produced by the parathyroid glands and regulates calcium and phosphate metabolism. PTH acts on PTHR1 receptors to stimulate bone formation and is used as a treatment for osteoporosis and hypoparathyroidism, a rare deficiency of parathyroid hormone [1,2]


Optimized synthesis of therapeutic MK2 inhibitor cell penetrating peptide: reduction in synthesis time using parallel automated synthesis

Peptide based drug discovery and research is increasingly at the forefront in addressing new therapeutic challenges due to their high target selectivity and potency with low toxicity. Automated solid phase peptide synthesis (SPPS) increases reliability, efficiency and crude purity for peptides in drug discovery and development.


Synthesis of [des-Arg7]-Dynorphin A peptoid analogue: faster methods using parallel automated synthesis and induction heat

High-throughput parallel synthesis optimization of Glucagon-like Peptide 1 receptor agonists

Poster presented at EPS2018


Synthesis of therapeutic stapled peptides: Fully automated peptide cyclization via olefin metathesis

Poster presented at EPS2018


Therapeutic Peptides: Synthesis Optimization Using Parallel Automated SPPS

Poster presented at EPS2018