Gyrolab Resources

Find technical documentation on our products as well as scientific references. 

Quantitation of Antibody-Drug Conjugates
Using Gyrolab systems, a generic IgG assay and an assay to measure payloads of ADCs can quickly be developed in parallel. 
[Application Note]

Maximizing productivity in biopharmaceutical research and clinical development
Three case studies are presented: "Obtaining an entire PK profile form a single mouse", "Earlier and more sensitive detection of drug-induced kidney toxicity in preclinical studies" and "Ramping up Phase II/III PK studies to meet critical deadlines". 
[Application Note]

Rapid determination of high-affinity KDs using Gyrolab systems
Gyrolab immunoassay platforms enable rapid and accurate determination of affinity interactions, down to picomolar KD, by measuring free unmodified interactants in equilibrated solutions. 
[Application Note]

Quantitation of Host Cell Protein Impurities
Gyrolab HCP assays deliver high precision results over a broad dynamic range, minimizing repeat analysis in bioprocess development and production. 
[Application Note]

Comparison of five immunoassays specific for CHO HCP using Gyrolab
Gyros Protein Technologies offers a range of five ready-to-use kits to measure HCP impurities from Chinese Hamster Ovary cells (CHO), based on commercially available antibody preparations. 
[Application Note]

Immunoassays to maximize productivity in bioprocess development
Gyrolab systems meet the needs of many biopharmaceutical companies that apply immunoassays to bioanalysis throughout bioprocess development. Gyrolab immunoassay platform addresses bottlenecks and delays by providing rapid assay development time, automation, high throughput, and a broad dynamic range that minimizes dilutions and repeats.  
[Application Note]

Quantitation of active GLP-1
GLP-1 is a gut hormone that is secreted in response to food intake, affecting both metabolism and weight. Since endogenous levels of GLP-1 are typically less than 5 pM in diabetes and obesity, the chosen method must have high sensitivity. Gyros Protein Technologies has developed an automated immunoassay for human active GLP-1 using commercially available reagents. 
[Application Note]

Miniaturizing immunoassays for improved performance (AR 207)
Application Report data courtesy of Lund University and Cambridge Antibody Technology. 
[Application Report]

Single-system solution for quantification of monoclonal IgG and host cell proteins (HCP) (AR 206)
Application Report data courtesy of AstraZeneca and GE Healthcare. 
[Application Report]

Quantification of antigen-specific antibodies in serum (AR 205)
Application Report data courtesy of National Veterinary Institute, Sweden. 
[Application Report]

Insulin quantification: save sample and increase efficiency (AR 204)
Application Report data courtesy of Karolinska Institute and Novo Nordisk. 
[Application Report]

Gyrolab Systems
Gyrolab technology reduces manual labor, assay development time, time to result and material consumption -and it improves workflow efficiency. 
[Brochure]

Gyrolab Kits
Gyrolab ready to use kits for CHO-HCP, Protein A and IgG titer analysis increase productivity in bioprocess development and QC. 
[Brochure]

Gyrolab Functionality Check
Please download and read the instructions for use before using Gyrolab Functionality Kit 
[Instruction for use]

Gyrolab CHO-HCP Kit 1 CD50
Please download and read the instructions for use before using Gyrolab CHO-HCP Kit 1 
[Instruction for use]

Gyrolab hulgG Kit
Please download and read the instructions for use before using Gyrolab huIgG Kit 
[Instruction for use]

Gyrolab CDs
Please download and read the instructions for use before using Gyrolab CDs 
[Instruction for use]

Rexxip Buffer
Please download and read the instructions for use before using Gyrolab Rexxip Buffer 
[Instruction for use]

Gyrolab Protein A Kit
Please download and read the instructions for use before using Gyrolab Protein A Kit 
[Instruction for use]

Gyrolab CHO-HCP Kit 1
Please download and read the instructions for use before using Gyrolab CHO-HCP Kit 1 
[Instruction for use]

Gyrolab CHO-HCP Kit 2-5
Please download and read the instructions for use before using Gyrolab CHO-HCP Kit 2-5 
[Instruction for use]

Gyrolab Generic PK Kit
Please download and read the instructions for use before using Gyrolab Generic PK Kit 
[Instruction for use]

Gyrolab Generic TK Kit
Please download and read the instructions for use before using Gyrolab Generic TK Kit 
[Instruction for use]

Rexxip Buffer
Material Safety Data Sheet for Rexxip products. 
[MSDS]

Gyrolab Functionality Check Reagent & Wash buffer
Material Safety Data Sheet for Gyrolab Functionality Check Kit Reagent and Wash Buffer 
[MSDS]

Gyrolab Protein A Kit Reagent D
Material Safety Data Sheet Gyrolab Protein A Kit Reagent D 
[MSDS]

Gyrolab Protein A Kit Reagents
Material Safety Data Sheet Gyrolab Protien A Kit Reagents 
[MSDS]

Gyrolab CHO-HCP Kit Reagents
Material Safety DataSheet 
[MSDS]

Gyrolab CHO-HCP Kit Reagent C
Material Safety Data Sheet for Gyrolab CHO-HCP Kit Reagent C 
[MSDS]

Gyrolab hulgG Kit Reagents
Material Safety Data Sheet for Gyrolag huIgG Kit Reagents 
[MSDS]

Gyrolab huIgG Standard
Material Safety Data Sheet for Gyrolab huIgG Kit Standard 
[MSDS]

Gyrolab Generic PK Kit Reagents
Material Safety Data Sheet for Gyrolab Generic PK Kit Reagents 
[MSDS]

Gyrolab Training Courses
Gyrolab Training Courses provide comprehensive instruction for all stages of the Gyrolab immunoassay workflow, from preparation of samples to data evaluation. 
[Product information sheet]

Gyrolab Service and Support
Gyros Protein Technologies offers a range of service contracts as well as individual service options. 
[Product information sheet]

Gyrolab Rexxip buffers
Rexxip buffers are designed to ensure that every sample enters and flows optimally through the microfluidic channels of a Gyrolab CD 
[Product information sheet]

Gyrolab huIgG Kit
Use Gyrolab huIgG Kit to determine concentrations of intact human monoclonal antibodies of IgG1, IgG2 and IgG4 subtypes during cell line development. 
[Product information sheet]

Gyrolab Protein A Kit
Gyrolab Protein A Kit Quantifies MabSelect SuRe™ ligands and native Protein A residuals in bioprocess samples. 
[Product information sheet]

Gyrolab CHO-HCP Kit 2-5
Gyrolab CHO-HCP Kit 2-5 is a panel of kits to complement Gyrolab CHO-HCP Kit 1 and increase the possibility of finding a kit that best matches your bioprocess. 
[Product information sheet]

Gyrolab CHO-HCP Kit 1
Gyrolab CHO-HCP Kit 1 is designed to measure CHO Host Cell Proteins impurities with performance that addresses many of the limitations of ELISA. 
[Product information sheet]

Gyrolab ADA solutions
Gyrolab ADA solution provides nanoliter-scale methods for ADA detection using automated acid dissociation or offline incubation. Dedicated software facilitates data analysis for either screening or confirmatory results.  
[Product information sheet]

Gyrolab CDs
Select the appropriate CD for a specific immunoassay based on the required dynamic range, the analyte concentration, the quality of reagents and the assay format.  
[Product information sheet]

Gyrolab Software modules
Gyrolab Affinity Software module facilitates the design and evaluation of in-solution affinity experiments, using non-modified substances. The software guides you in defining the interacting pairs and setting up the affinity sample series. 
[Product information sheet]

Gyrolab xPlore
Gyrolab xPlore single-CD system automates high performance immunoassays throughout biopharma development and production. 
[Product information sheet]

Gyrolab xPand
Gyrolab xPand five CD system optimizes immunoassay development, processing and performance in your laboratory. 
[Product information sheet]

Gyrolab Wash Buffer pH 11
Gyrolab Wash Buffer pH11 is a biodegradable high-pH washing buffer that is highly effcient when used in combination with Rexxip buffers. 
[Product information sheet]

Gyrolab Generic PK-TK Kits
Gyrolab Generic PK/TK Kits quantifies human IgG1, IgG2, or IgG4 titer over a broad range in a number of matrices. 
[Product information sheet]

Capillary microsampling of liquid matrices. Better Science – Fewer Animals
New opportunities for collection and handling of extremely small volumes of biofluids – From early screen to late clinic. Ove Jonsson Global DMPK, AstraZeneca R&D, Södertälje, Sweden. 
[Poster]

Comparative HCP Testing Using Traditional and Emerging Technologies
Martha Jackson, David Cirelli, Phoebe Baldus, Ned Mozier. BioTherapeutics Pharmaceutical Sciences, Analytical Research and Development, Pfizer, Andover, MA 
[Poster]

Quantitative Ligand Binding Assay for Determination of Antibody Drug Conjugate Using Gyrolab Immunoassay Platform
Aidong Wu, Tracey Clark, Chad Ray, Frank Barletta, Erick Kindt, Scott Fountain, Pfizer Global R&D, USA 
[Poster]

One mouse one PK The magic of capillary microsampling and the Gyrolab assay platform
Sufyan Maqbool, Jo Goodman, David Fairman, Dominic Corkill, BSU & Bioanalytical Sciences, Clinical Pharmacology & DMPK (CPD) Ove Jonsson, Michael Spreadborough, Christopher Smith. MedImmune 
[Poster]

Development and validation on a pharmacokinetic assay on Gyrolab platform for use in Phase II/III clinical studies
M. Dula, S. Fernando et. al. Morphotek Bioanalytical Dev. 
[Poster]

A Simplified Process to Develop “Fit-for-Purpose” PK/PD Assays in Support of Early Drug Discovery Programs
Rong Liu, Renuka Pillutla, Binodh Desilva, Yan Zhang. BAS-Biologics, Bristol Myers Squibb, Princeton, NJ 
[Poster]

Evaluation of Gyrolab™ and Meso-Scale Discovery platforms in the development of a clinical immunogenicity assay
J Collet, A Moreau et. al. NovImmune SA, Geneva, Switzerland 
[Poster]

High Throughput Process-related Impurity Testing Using a Gyrolab™ Workstation
Meletios Roussis, Eric Beard, Keshavamurthy Prakash, Robert Strouse and Michael Washabaugh. Analytical Biochemistry, MedImmune, Gaithersburg, MD 20878 USA 
[Poster]

Product quantification (IgG Titer) using an automated analytical platform–Gyrolab workstation
Lin Wang, Ph.D., Li Zhang, Fang Li and Eike Zimmermann,Ph.D. Boehringer Ingelheim, Fremont CA, USA 
[Poster]

Gyrolab CHO-HCP kit panel simplifies HCP assay selection in bioprocess development
Gyros Protein Technologies offers a range of five ready-to-use kits to measure HCP impurities from Chinese Hamster Ovary cells (CHO), based on commercially available antibody preparations. 
[Poster]

A Generic Pharmacokinetic (PK)/ Toxicokinetic (TK) Assay Kit for Analysis of Biotherapeutic Antibodies in Sera from Several Species for Early-stage Development using Gyrolab™ Platforms
Ready to use Gyrolab Generic PK/TK kits streamlines evaluation of drug candidates for multiple programs using only nanoliter volumes and eliminates the time and resources needed for assay development and reagent screening.  
[Poster]

Development of residual host cell protein assays for recombinant microbial biopharmaceuticals
Katja Peiris and Daniel Schiwek, LCMD Analytical Development, Lonza AG, Switzerland 
[Poster]

Gyrolab Generic PK Assay: Determination of Human IgG in Preclinical Matrices
Recorded Webinar: Daniel Forsström, Scientist at Gyros Protein Technologies, presents data using a high performance generic PK assay kit optimized for use with Gyrolab automated nanoliter-scale immunoassay systems.  
[Webinar]

Rapid in-solution equilibrium approach to KD determination of biotherapeutic drug candidates
Recorded Webinar: Johan Engström, Senior Scientist at Gyros Protein Technologies, presents aspects of in-solution equilibrium affinity experiments using Gyrolab systems. 
[Webinar]

Streamlining product titer using automated nanoliter-scale immunoassays with throughput, dynamic range & reliable reproducibility
Recorded Webinar. Presenters: Matt Traylor, Analytical Development, Shire Human Genetic Therapies, “Rapid Development of Gyrolab Titer ELISAs to Support Biopharmaceutical Process Development” and Jun Heo, Analytical Scientist, Bioprocess Technology and Expression (BTE), Merck & Co., Inc., “High Throughput Monoclonal Antibody Titer Assay for BioProcess Development”. 
[Webinar]

Minimizing Repeats and Making Rapid Data Driven Decisions using Automated Nanoliter-scale Immunoassays for Impurity Testing in Bioprocess and Production
This recorded webinar focuses on the use of automated, nanoliter-scale flow-through technology to address a critical need for improved speed, throughput and reduced repeats in process related impurity testing. Presenters: Martha L. Jackson, Senior Research Scientist, Pfizer Inc. and Jun Hyuk Heo, Biochemist, Biotechnology New and Enabling Technologies (BNET), Merck & Co. 
[Webinar]

Assessing the immunogenicity of biopharmaceuticals
Recorded Webinar: Immunogenicity of therapeutic biopharmaceuticals can impact both the efficacy and the safety of the product. Assessment of anti-drug antibodies (ADAs) as well as neutralizing antibodies (NAbs) is a fundamental part of immunogenicity testing. Presenters: Cecilia Bill, Gyros Protein Technologies and Frida Pauly, Euro Diagnostica. 
[Webinar]

Rapid Reagent Screening and Characterization using Automated Nanoliter-scale Immunoassays
Recorded Webinar: Gyrolab is a reliable immunoassay platform that streamlines reagent selection and characterization during method development for biotherapeutics. Presenters: Frank Zambito, Research Scientist I, Bioanalytical Sciences, Bristol-Myers Squibb and Shawn Fernando, Senior Principal Researcher, Morphotek, Inc. 
[Webinar]

Using Automated Nanoliter-Scale Immunoassays for Improved Performance and Efficiency
Recorded Webinar: Christophe Henry, Ph.D., Laboratory Head / Translational Medicine, Sanofi, presents case studies featuring reagent screening and method development for a variety of different biotherapeutics – traditional and non-conventional constructs. 
[Webinar]

Automating Pharmacokinetic Bioanalysis at Nanoliter-Scale: Strategies for Development, Validation and Transfer
Recorded Webinar: “Detection of human IgG matrices: A universal approach”, Sufyan Maqbool, Associate Scientist I, Clinical Pharmacology and DMPK, MedImmune Cambridge UK and “Transfer and validation of a Gyrolab PK assay to a CRO”, Emilie Escoffier, MSc Biochemistry & Biotechnology, Research Assistant, Exploratory Science and,Translational Medicine, NovImmune SA, Geneva, Switzerland. 
[Webinar]

Automated Pharmacokinetic Bioanalysis at Nanoliter-Scale: From Early Stage Development to Validation and Transfer for Clinical Studies
Recorded webinar focusing on the implementation of the Gyrolab workstation for automated PK bioanalysis in support of early stage development, regulated bioanalysis and clinical trials. Presenters: Vimal Patel, Senior Associate Scientist, Amgen, Thousand Oaks, CA, USA, Jo Goodman, Senior R&D Manager, MedImmune, Cambridge, UK, and Shawn Fernando, Senior Researcher, Bioanalytical Development, Morphotek, Exton, PA, USA. 
[Webinar]

Redefining 3Rs for Safety Toxicology Biomarkers using Automated Nanoliter-scale Immunoassays
Recorded Webinar. Presenters: Diane Marie Hamlin, Investigative Toxicology, Eli Lilly and Wei Zheng, Immunoassays & Multiplexing, Bioscience, EMD Millipore. 
[Webinar]

Challenges of supporting multiple programs for PK Bioanalysis: a CRO perspective
Recorded Webinar: Contract Research Organisations (such as Envigo) are required to transfer, develop, validate and carry out sample analysis on a wide range of drug products from clients. Discussed are various aspects that must be considered when choosing a suitable assay platform for pharmacokinetic (PK) studies. Presenter: Deborah McManus Senior Technical Specialist in the Department of Biomarkers, Bioanalysis and Clinical, Envigo UK. 
[Webinar]

Automated nanoliter-scale immunoassays to maximize productivity in bioprocess development
Recorded Webinar: Karolina Österlund, Manager Field Application Scientists EU and Asia, Gyros Protein Technologies AB, presents Gyrolab™ systems and a range of easy-to-use immunoassay kits as an automated, high-throughput platform for cell line and bioprocess development, illustrated by case studies from Shire, MedImmune and Merck. 
[Webinar]

Fit-for-Purpose Biomarker Assay Development and Validation using Automated Nanoliter-Scale Immunoassays
Recorded Webinar. Presenters: Robert Durham, Ph.D., Gyros Inc., Chad A. Ray, PhD, Pfizer PDM, Kerry Oliver, Ph.D., Radix Biosolutions & Ariëlla Van de Sompel, Senior Research Associate, Ablynx. 
[Webinar]

Overcoming Disease Specific Matrix Effects in a Clinical Pharmacokinetic Assay
Recorded Webinar. Presenter Kathi J. Williams, Senior Scientific Researcher Assay Development and Technology, Genentech, Inc 
[Webinar]

Critical Reagent Characterization on Gyrolab using Solution Based Affinity Module: A Case Study
Recorded Webinar: Presenter Alison Joyce, Senior Principal Scientist, Biomedicine Design, Discovery Bioanalytical and Critical Reagent Group, Pfizer Inc. 
[Webinar]

Streamlined and automated immunoassays adapted for bioprocess workflows accelerate QbD strategy initiatives
Recorded Webinar: Presenter Daniel Forsström, application scientist at Gyros Protein Technologies  
[Webinar]

Shawn Fernando PK assays: Gyrolab helps to meet tight deadlines
Recorded Seminar: Shawn Fernando,  Senior Researcher, Bioanalytical Development, Morphotek, Exton, PA, USA, presents ‘Development and Validation of a Pharmacokinetic Assay on the Gyrolab Platform for Use in Phase II/III Clinical Trials'. 
[Seminar]

Annette Wu shows how Gyrolab xP workstation speeds up ADC assay development and throughput
Recorded Seminar: Annette Wu in the PDM group at Pfizer, La Jolla, CA, USA, presents ‘Case study: Antibody-drug conjugates TK study on Gyros' immunoassay platform'. 
[Seminar]

Sabrina Lory Developing fit-for-purpose immunoassays
Recorded Seminar: Sabrina Lory, Head of the Bioanalytical Assay Laboratory, NovImmune, presents ‘Developing fit for purpose assays using the Gyrolab platform'. 
[Seminar]

Mark Dysinger GLP-1 quantitation: Gyros vs. other detection platforms
Recorded Seminar: Mark Dysinger, Senior Scientist, Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, presents ‘Glucagon-Like Peptide 1 Quantitation: Gyros vs Other Detection Platforms'. 
[Seminar]

Diane Hamlin on the performance of Gyrolab xP workstation
Recorded Seminar: Diane Hamlin, Eli Lilly and Company, presents 'Performance of the Gyrolab xP System for Custom Development of Preclinical Urinary Renal Biomarker Assays'. 
[Seminar]

Jun Heo on using Gyrolab xP to automate high throughput HCP analysis
Recorded Seminar: Jun Heo, Analytical Biochemist, Biologics-New and Enabling Technologies (BNET), Merck & Co., Inc., presents 'The Automation of a High Throughput Residual Assay to Support In-Process Analysis of Monoclonal Antibodies'. 
[Seminar]

Daniel Schiwek on The value of Gyrolab xP workstation in HCP analysis and bioprocess
Recorded Seminar: Daniel Schiwek, Project Evaluation Manager at Global Biological Operations, Lonza AG, Visp, Switzerland, presents ‘Biopharmaceutical manufacturing in microbial systems – Gyrolab as an analytical platform supporting process development'. 
[Seminar]

Cobra Biologics on the versatility of Gyrolab™ immunoassay platform in bioprocess development
Anna Lönnerbro is an Analytical Scientist at Cobra Biologics, a CMO and CRO of biologics and pharmaceuticals for pre-clinical, clinical and commercial supply. Cobra Biologics offers support from small scale-up to large-scale bioprocess. Presenting at Gyrolab User Seminar in Copenhagen, Denmark on June 2, 2014, Anna described how the Gyrolab platform enables Cobra Biologics to deliver premium services with improved immunoassays.  
[Case Study]

Combine DOE and Gyrolab system to quickly develop robust immunoassays
Two assay development teams at Pfizer have combined the systematic approach of DOE and the Gyrolab platform to streamline the development of robust immunoassays.  
[Case Study]

How to get more reliable results with less effort
Analytical results that you can depend on are crucial to success, especially in a regulated environment. For example, immunoassays that consistently deliver reliable data with high accuracy and precision are worth their weight in gold. ELISA has been the standard for immunoassays, but this situation is changing. We present here two case studies that show how a move from ELISA to Gyrolab™ assays is helping your colleagues to improve their results and lab workflows. 
[Case Study]

Validation and implementation of a pharmacokinetic assay on the Gyrolab™ platform for use in GLP toxicology study
Case study based on a poster by P. Verdier, A Choquart, N. Macé, and M-H Pascual, Biomarkers and Clinical Bioanalyses, Translational Medicine and Early Development, Sanofi, Paris, France. The poster was presented at the European Gyrolab Seminar in Paris, June 2017. 
[Case Study]

The challenging road to success: from ELISA to Gyrolab™ via MSD
Envigo were asked by a client to develop and validate a PK/TK assay for a monoclonal antibody used to treat cancer at levels as low as 10 ng/ml in cyno samples. The company first transferred the assay from ELISA to the MSD platform before finally transferring it to Gyrolab™ system, where the development and validation work was completed. Sarah Geen described the challenges encountered throughout this process and the strategies used to overcome them at the European Gyrolab Seminar in Amsterdam in June 2016.  
[Case Study]

One Mouse, One PK…the Magic of Capillary Microsampling and Gyrolab
Sufyan Maqbool is an Associate Scientist in Clinical Pharmacology and DMPK at MedImmune, in Cambridge, UK. His recent work has focused on developing capillary microsampling (CMS) methodologies for PK assays. On June 2, 2014 he presented his work at the Gyrolab User Seminar in Copenhagen, Denmark.  
[Case Study]