PurePep® SONATA®+

upgrades for Sonata XT

Mid-Pilot Scale Peptide Synthesizer

With PurePep® Pathway and Real-Time Flow Technology 

Request a quote

PurePep Sontata+
  • Real-Time Flow Technology – accurate and precise fluid transfers with with minimal need to calibrate
  • Pre-programmed standard methods – use as is, or as a template for customized methods
  • Import sequences – easily create syntheses from focused libraries
  • Multi-task – plan one synthesis while another is running
  • Auto-calculations – reagent preparation, cost and usage calculators built into the software
  • Variable Mixing Modes – nitrogen bubbling, agitation and recirculation for increased purity
PurePep Pathway “Inside”
The design power of the proprietary PurePep Pathway (valve block system) results in zero dead volumes, no cross-contamination, and worry-free performance that lasts for years. Other systems use off-the-shelf valves that leak, cross-contaminate, and quickly fail when exposed to harsh peptide synthesis chemicals. With the trusted PurePep Pathway inside Sonata XT, you have reliable peptide purity every time.
Real-Time Flow Technology
This is a non-invasive method of continually monitoring the flow rate of fluids within the system. Fluids are delivered precisely and accurately, even for those with different viscosities, with minimal need for calibration.
Enhanced pumps and other hardware
Faster primary solvent pump. Upgraded recirculation pump enabling less maintenance. Easy connection to external solvent and waste systems. Greater flexibility with new GL45-type amino acid bottle setup. Higher purity and no risk of reagent cross-contamination with Single-Shot™ preactivation.
Multiple mixing modes
Sonata XT has chemically inert, optimized channels allowing high solution transfer rates (> 400 mL/min) of any solvent. All reactions occur in an inert environment to minimize side reactions. Multiple mixing modes including nitrogen bubbling (adjustable), agitation and recriculation which can be used alone or combined to maximize reaction efficiency.

Solvent and reagent positions

Seven solvent ports and twenty reagent ports allow easy customization for any synthesis protocol. Real-Time Flow technology allows precise delivery of all solvents and reagents. To minimize disposal costs, two waste ports allow waste streams to be separated. A collection port can be implemented for cleavage product or valuable reagent recovery for maximum versatility.

Intuitive software

The icon-driven software simplifies the chemist’s workflow and accelerates set up of peptide synthesis methods. Pre-programmed methods may be used as is, or as a template for customized methods and sequences can be easily imported to avoid errors. Increase your productivity and program new syntheses while others are already running. The software is designed for 21 CFR part 11 compliance.


Installation qualification and operation qualification (IQ/OQ) support services verify and document that your instrument is supplied, installed, and operating according to GPT specifications, and may be required for operating under cGMP conditions. GPT-certified field service engineers inspect critical components, ensure that your systems function properly and reproducibly during automated synthesis operations, and provide documentation to help you meet regulatory requirements. Read more.


Number of reaction vessels
Synthesis scale range
1 mmol to 200 mmol
Reaction vessel volume
200 mL, 500 mL, 1.2 L, 2 L, 3.2 L, 4.2 L
Number of solvent positions/sizes
1 primary solvent, 1 L - 200 L capacity.
(User-supplied or optional vessel available)
6 user-defined solvent positions, 0.5 L - 4 L capacities
Number of amino acid positions
20 amino acid / positions, 500 mL or 1 L
Chemistries supported
Fmoc, t-Boc, organic, peptoid, combinatorial, other

Fluid measurement technique

Real-Time Flow delivery of fluids
Fluid transfer method
Positive pressure with nitrogen for most solvents and reagents
Dedicated pump for primary solvent
Agitation method
Nitrogen bubbling (adjustable), variable vortexing, recirculation
-Alone or in Combination
Automatic, programmable (for Fmoc chemistry only)
Waste container
(2) 20 L containers with overflow sensor
-200 L option available
Control interface
Proprietary PurePep software. Stand-alone computer, flat panel monitor and printer included
Real-time log of each instrument function, print to file or printer. Includes e-mail notifications to send an email to a computer or cell phone at a specified program step, at the beginning of each cycle, or if an error occurs

115 V/60 Hz or 230 V/50 Hz

35”W, 23”D, 63.5”H (89 cm W, 58 cm D, 161 cm H)
400 lbs. (182 kg)
One year, parts and labor

PurePep Reagents



Coupling Agents


Your peptide synthesis needs are important to us. If you would like custom packaging, other special handling conditions, or a quote please send us your request here peptides@gyrosproteintech.com


All instrument accessories and spare parts are available to order in our online shop, you can open the PurePep Sonata+, Sonata/Sonata X accessories here