Peptide Synthesis Applications

Gain insight into how Protein Technologies' platforms have been applied in research and development related to biomaterials, drug delivery, peptide therapeutics, vaccines and venoms & toxins.

Click on the image below to download the white paper

Download the white paper

Downloat the white paper





Drug delivery


Directing the phase behavior of polyelectrolyte complexes using chiral patterned peptides.
Pacalin N.M. et al. EPJ ST October 2016, Volume 225, Issue 8, pp 1805-1815.2016

Endosomolytic Nano-Polyplex Platform Technology for Cytosolic Peptide Delivery To Inhibit Pathological Vasoconstriction.
Evans B.C. et al. ACS Nano, 9(6), 5893-5907. 2015

Intracellular Delivery System for Antibody Peptide Drug Conjugates.
Berguig G.Y. et al. Molecular Therapy, 23(5), 907-917. 2015

Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity.
Chu D.S.H. et al. Journal of Controlled Release: Official Journal of the Controlled Release Society, 205, 155-161. 2015

Dual MMP7-Proximity-Activated and Folate Receptor-Targeted Nanoparticles for siRNA Delivery.
Li H. et al.  Biomacromolecules, 16(1), 192-201.2015

Enhanced cellular uptake of short polyarginine peptides through fatty acylation and cyclization.
Oh D et al.  Molecular pharmaceutics 11.8 (2014): 2845-2854.2014

Enhanced efficacy of combination heat shock targeted polymer therapeutics with high intensity focused ultrasound.
Frazier N. et al. Biology and Medicine2016

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics
Lönn P. et al. Scientific Reports 6, Article number: 32301 (2016).2016

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.
Mourtada R. et al. PLoS One. 2013 Apr 9;8(4).2013

Evaluation of Doxorubicin-Loaded 3-Helix Micelles as Nanocarriers
Dube N. et al. Biomacromolecules. 2013 Oct 14;14(10):3697-705.2013

Targeted delivery of doxorubicin to mitochondria
Chamberlain G.R. et al. ACS Chem. Biol., 2013, 8 (7), pp 1389–1395.2013

Tuning Liposome Membrane Permeability by Competitive Peptide Dimerization and Partitioning-Folding Interactions Regulated by Proteolytic Activity
Lim S.K. et al. Scientific Reports 6, Article number: 21123 .2016

Optimization of the cyclotide framework to improve cell penetration properties.
Huang Y.-H. et al. Front Pharmacol. 2015; 6: 17.2015

Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
Huang Y.-H. et al. Scientific Reports 5, Article number: 12974.2015

A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density.
Gray B.P. et al. PLoS One. 2013 Aug 23;8(8):e72938.2013

MRI-visible micellar nanomedicine for targeted drug delivery to lung cancer cells.
Guthi J.S. et al. Mol Pharm. 2010 Feb 1;7(1):32-40.2010

Peptide nanoparticle with pH-sensing cargo solubility enhances cancer drug efficiency
Choi H. et al. Nano Today, Available online 22 March 2017.2017

Self-assembly of Filamentous Cell Penetrating Peptides for Gene Delivery
Xu D. et al. Peptide Self-Assembly. Methods in Molecular Biology, vol 1777. Humana Press, New York, NY.2018

Cisplatin-loaded hollow gold nanoparticles for laser-triggered release
Xiong C. et al. Cancer Nano (2018) 9: 6.2018

Injectable Supramolecular Hydrogel/Microgel Composites for Therapeutic Delivery
Chen M.H. et al. Macromol. Biosci. 2018, 1800248. 2018

Solid-Phase Zincke Reaction for the Synthesis of Peptide-4,4′-bipyridinium Conjugates
Corton, P, et al. Synthesis2019

Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold
Huawu Yin, et al. ChemRxiv. 2020

Noninvasive Brain Delivery and Efficacy of BDNF to Stimulate Neuroregeneration and Suppression of Disease Relapse in EAE Mice
Brian M. Kopec, et al. Mol. Pharmaceutics2020