Gain insight into how Protein Technologies' platforms have been applied in research and development related to biomaterials, drug delivery, peptide therapeutics, vaccines and venoms & toxins.
Read our new article “Turning up the heat on peptide purity” in Chemistry Today to learn how:
Parallel synthesis optimization was performed on the Prelude X for the preparation of difficult and biologically active peptides
Optimized methods with induction heating can be used to achieve a 5-fold decrease in reaction time and 4-fold increase in crude purity
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Wade R. J. et al. Nature Communications, 6, 6639. 2015
A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel.
Frohm B. et al. Soft matter 11.2 (2015): 414-421.2015
Photoresponsive elastic properties of azobenzene-containing poly(ethylene-glycol)-based hydrogels.
Rosales A. M. et al. Biomacromolecules, 16(3), 798-806.2015
Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition.
Sridhar B. V. et al. Advanced Healthcare Materials, 4(5), 702-713.2015
Design of thiol-ene photoclick hydrogels using facile techniques for cell culture applications
Sawicki L. A. et al. Biomaterials Science, 2(11), 1612-1626.2014
Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.
Kuo C.-H. et al. Journal of Materials Chemistry. B, Materials for Biology and Medicine, 2(46), 8142-8153.2014
Design and characterization of a synthetically accessible, photodegradable hydrogel for user-directed formation of neural networks.
McKinnon D. D. et al. Biomacromolecules 15.7 (2014): 2808-2816.2014
A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration.
Singh S. P. et al. Biomaterials Science, 2(7), 1024-1034.2014
Mechanical memory and dosing influence stem cell fate.
Yang C. Nature Materials, 13(6), 645-652.2014
Measuring cellular forces using bis-aliphatic hydrazone crosslinked stress-relaxing hydrogels.
McKinnon D.D. et al. Soft Matter, 10(46), 9230-9236.2014
Origins of Structural Flexibility in Protein-Based Supramolecular Polymers Revealed by DEER Spectroscopy.
Tavenor N. A. et al. The Journal of Physical Chemistry. B, 118(33), 9881-9889.2014
The Role of Valvular Endothelial Cell Paracrine Signaling and Matrix Elasticity on Valvular Interstitial Cell Activation.
Gould S.T. et al. Biomaterials, 35(11), 3596-3606.2014
Secondary Photocrosslinking of Injectable Shear‐Thinning Dock‐and‐Lock Hydrogels
Lu H.D. et al. Advanced healthcare materials 2.7 (2013): 1028-1036.2013
Diels–Alder mediated controlled release from a poly (ethylene glycol) based hydrogel.
Koehler K.C. et al. Biomacromolecules 14.2 (2013): 538-547.2013
Role of Cell-Matrix Interactions on VIC Phenotype and Tissue Deposition in 3D PEG Hydrogels.
Gould S.T. and Anseth K.S. Journal of Tissue Engineering and Regenerative Medicine, 10.1002/term.1836.2013
Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate.
Leight J.L. et al. Biomaterials, 34(30), 7344–7352.2013
Three-dimensional hMSC Motility within Peptide-Functionalized PEG-Based Hydrogel of Varying Adhesivity and Crosslinking Density.
Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly (ethylene glycol)-block-polylactide.
Chen W.L. et al. Biomaterials. 2014 Feb;35(5):1686-95.2014
Phosphorylation-dependent mineral-type specificity for apatite-binding peptide sequences
Addison W.N. et al. Biomaterials. 2010 Dec;31(36):9422-30.2010
The adsorption of preferential binding peptides to apatite-based materials.
Segvich S.J. et al. Biomaterials Volume 30, Issue 7, March 2009, Pages 1287–1298.2009
High In Vitro Antibacterial Activity of Pac-525 against Porphyromonas gingivalis Biofilms Cultured on Titanium
Li J. et al BioMed Research International Volume 2015 (2015), Article ID 909870.2015
Self-sorting heterodimeric coiled coil peptides with defined and tuneable self-assembly properties.
Aronsson C. et al. Sci Rep. 2015; 5: 14063.2015
Anchoring a Cytoactive Factor in a Wound Bed Promotes Healing.
Chattopadhyay S. et al. J Tissue Eng Regen Med. 2016 Dec;10(12):1012-1020.2014
A photoclickable peptide microarray platform for facile and rapid screening of 3-D tissue microenvironments
Sharma S.et al. Biomaterials, Volume 143, October 2017, Pages 17-28.2017
Rapid Bioorthogonal Chemistry Enables in Situ Modulation of the Stem Cell Behavior in 3D without External Triggers
Hao Y. et al. ACS Appl. Mater. Interfaces, 2018, 10 (31), pp 26016–26027.2018
Effect of Processing and End Groups on the Crystal Structure of Polypeptoids Studied by Cryogenic Electron Microscopy at Atomic Length Scales
Jiang X. et al. Soft Matter, 2019, Accepted Manuscript.2019
Sorafenib encapsulated in nanocarrier functionalized with glypican-3 specific peptide for targeted therapy of hepatocellular carcinoma
Shuoe Feng, et al. Colloids and Surfaces B: Biointerfaces2019
Peptides from diatoms and grasses harness phosphate ion binding to silica to help regulate biomaterial structure
Adiram-Filiba, N. et al. Acta Biomaterialia2020
Design, characterization and evaluation of ?-hairpin peptide hydrogels as a support for osteoblast cell growth and bovine lactoferrin delivery
De Leon-Rodrigues, L. et al. RSC Advances2020
Design, characterization and evaluation of ?-hairpin peptide hydrogels as a support for osteoblast cell growth and bovine lactoferrin delivery
De Leon-Rodriguez, L. et al. RSC Adv.
Design, characterization and evaluation of ?-hairpin peptide hydrogels as a support for osteoblast cell growth and bovine lactoferrin delivery
