Peptide Synthesis Applications

Gain insight into how Protein Technologies' platforms have been applied in research and development related to biomaterials, drug delivery, peptide therapeutics, vaccines and venoms & toxins.

View recorded webinar: Chemical, Computational, and Instrumental Tools for Challenging Peptide Syntheses. >>
Speaker: Michael S Kay, MD/PhD, Professor. Biochemistry, University of Utah

Review articles on GEN BioPerspectives published in December 2016 >>

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Multifunctional thermoresponsive designer peptide hydrogels.
De Leon-Rodriguez L.M. et al. Acta Biomaterialia Volume 47, 1 January 2017, Pages 40–49.2016

Biocompatibility and Characterization of a Peptide Amphiphile Hydrogel for Applications in Peripheral Nerve Regeneration.
Black K.A. et al. Tissue Engineering. Part A, 21(7-8), 1333-1342. 2015

Protease degradable electrospun fibrous hydrogels.
Wade R. J. et al.  Nature Communications, 6, 6639. 2015

A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel.
Frohm B. et al.  Soft matter 11.2 (2015): 414-421.2015

Photoresponsive elastic properties of azobenzene-containing poly(ethylene-glycol)-based hydrogels.
Rosales A. M. et al. Biomacromolecules, 16(3), 798-806.2015

Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition.
Sridhar B. V. et al. Advanced Healthcare Materials, 4(5), 702-713.2015

Design of thiol-ene photoclick hydrogels using facile techniques for cell culture applications
Sawicki L. A. et al. Biomaterials Science, 2(11), 1612-1626.2014

Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.
Kuo C.-H. et al. Journal of Materials Chemistry. B, Materials for Biology and Medicine, 2(46), 8142-8153.2014

Design and characterization of a synthetically accessible, photodegradable hydrogel for user-directed formation of neural networks.
McKinnon D. D. et al. Biomacromolecules 15.7 (2014): 2808-2816.2014

A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration.
Singh S. P. et al. Biomaterials Science, 2(7), 1024-1034.2014

Mechanical memory and dosing influence stem cell fate.
Yang C.  Nature Materials, 13(6), 645-652.2014

Measuring cellular forces using bis-aliphatic hydrazone crosslinked stress-relaxing hydrogels.
McKinnon D.D. et al. Soft Matter, 10(46), 9230-9236.2014

Origins of Structural Flexibility in Protein-Based Supramolecular Polymers Revealed by DEER Spectroscopy.
Tavenor N. A. et al. The Journal of Physical Chemistry. B, 118(33), 9881-9889.2014

The Role of Valvular Endothelial Cell Paracrine Signaling and Matrix Elasticity on Valvular Interstitial Cell Activation.
Gould S.T. et al. Biomaterials, 35(11), 3596-3606.2014

Secondary Photocrosslinking of Injectable Shear‐Thinning Dock‐and‐Lock Hydrogels
Lu H.D. et al.  Advanced healthcare materials 2.7 (2013): 1028-1036.2013

Diels–Alder mediated controlled release from a poly (ethylene glycol) based hydrogel.
Koehler K.C. et al. Biomacromolecules 14.2 (2013): 538-547.2013

Role of Cell-Matrix Interactions on VIC Phenotype and Tissue Deposition in 3D PEG Hydrogels.
Gould S.T. and Anseth K.S. Journal of Tissue Engineering and Regenerative Medicine, 10.1002/term.1836.2013

Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate.
Leight J.L. et al. Biomaterials, 34(30), 7344–7352.2013

Three-dimensional hMSC Motility within Peptide-Functionalized PEG-Based Hydrogel of Varying Adhesivity and Crosslinking Density.
Kyburz K.A. & Anseth K.S.  Acta Biomaterialia, 9(5), 6381–6392.2013

Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly (ethylene glycol)-block-polylactide.
Chen W.L. et al. Biomaterials. 2014 Feb;35(5):1686-95.2014

Phosphorylation-dependent mineral-type specificity for apatite-binding peptide sequences
Addison W.N. et al. Biomaterials. 2010 Dec;31(36):9422-30.2010

The adsorption of preferential binding peptides to apatite-based materials.
Segvich S.J. et al. Biomaterials Volume 30, Issue 7, March 2009, Pages 1287–1298.2009

High In Vitro Antibacterial Activity of Pac-525 against Porphyromonas gingivalis Biofilms Cultured on Titanium
Li J. et al BioMed Research International Volume 2015 (2015), Article ID 909870.2015

Self-sorting heterodimeric coiled coil peptides with defined and tuneable self-assembly properties.
Aronsson C. et al. Sci Rep. 2015; 5: 14063.2015

Anchoring a Cytoactive Factor in a Wound Bed Promotes Healing.
Chattopadhyay S. et al. J Tissue Eng Regen Med. 2016 Dec;10(12):1012-1020.2014

A photoclickable peptide microarray platform for facile and rapid screening of 3-D tissue microenvironments
Sharma al. Biomaterials, Volume 143, October 2017, Pages 17-28.2017