Peptide Synthesis Applications

Gain insight into how Protein Technologies' platforms have been applied in research and development related to biomaterials, drug delivery, peptide therapeutics, vaccines and venoms & toxins.

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Venoms and Toxins


Baltikinin: A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea.
Shi D. et al. Toxins, 8(7), 213.2016

AaeAP1 and AaeAP2: Novel Antimicrobial Peptides from the Venom of the Scorpion, Androctonus aeneas: Structural Characterisation, Molecular Cloning of Biosynthetic Precursor-Encoding cDNAs and Engineering of Analogues with Enhanced Antimicrobial and Anticancer Activities.
Du Q. et al. Toxins, 7(2), 219-237. 2015

Mambalgin-1 pain-relieving peptide: stepwise solid-phase synthesis, crystal structure and functional domain for acid-sensing ion channel 1a inhibition
Mourier G. et al. J. Biol. Chem. jbc.M115.702373. doi:10.1074/jbc.M115.702373 2015

Improved Detection of Botulinum Neurotoxin Serotype A by Endopep-MS through Peptide Substrate Modification
Wang D. et al. Analytical Biochemistry, 432(2), 115–123.2013

Comparison of the Catalytic Properties of the Botulinum Neurotoxin subtypes A1 and A5.
Wang D. et al. Biochimica et Biophysica Acta, 1834(12), 2722–2728.2013

High-throughput production of two disulphide-bridge toxins
Upert G. et al. Chem Commun (Camb). 2014 Aug 7;50(61):8408-11.2014

Kv1. 3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases
Chhabra S. et al. FASEB J. 2014

Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers.
Falcao C.B. et al. Amino Acids. 2014 Nov;46(11):2561-71.2014

δ-Conotoxins Synthesized Using an Acid-cleavable Solubility Tag Approach Reveal Key Structural Determinants for NaV Subtype Selectivity.
Peigneur S. et al. J Biol Chem. 2014 Dec 19; 289(51): 35341–35350.2014

New α-adrenergic property for synthetic MTβ and CM-3 three-finger fold toxins from black mamba.
Blanchet G. et al. Toxicon. 2013 Dec 1;75:160-7.2013

Peptidomic comparison and characterization of the major components of the venom of the giant ant Dinoponera quadriceps collected in four different areas of Brazil
Cologna C.T. et al. Journal of Proteomics Volume 94, 6 December 2013, Pages 413–422.2013

Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.
Chinchar V.G. et al. Virology. 2004 Jun 1;323(2):268-75.2004

Expression, activation, and processing of the recombinant snake venom metalloproteinase, pro-atrolysin E.
Shimokawa K. et al. Arch Biochem Biophys. 1996 Nov 15;335(2):283-94.1996

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain
Deuis J.R. et al. Toxins 2016, 8(3), 78.2016

Enhanced detection of type C botulinum neurotoxin by the Endopep-MS assay through optimization of peptide substrates.
Wang D. et al. Bioorg Med Chem. 2015 Jul 1;23(13):3667-73.2015

‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency
Ziegman R. et al. Mar. Drugs 2019, 17(3), 165.2019

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels
Jin A.-H. et al. Biochemical Pharmacology, In Press, Accepted Manuscript.2019

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor
Chambers C. et al.  FEBS Lett. Accepted Author Manuscript. 2019

Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
Pedron C.N. et al. Bioorganic Chemistry,Available online 8 June 2019, 103038, In Press, Accepted Manuscript.2019

The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1
Pedron C.N. et al. European Journal of Pharmaceutical Sciences, Available online 7 June 2019. In Press, Accepted Manuscript.2019

Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1
Nicolas, S. et al. Toxins2019

The wasp venom antimicrobial peptide polybia-CP and its synthetic derivatives display antiplasmodial and anticancer properties
Torres, M. et al. bioengineering & translational medicine2020

Wasp venom peptide as a new antichagasic agent
Albuquerque Freire, K. et al. Toxicon2020