Peptide Synthesis Applications

Gain insight into how Protein Technologies' platforms have been applied in research and development related to biomaterials, drug delivery, peptide therapeutics, vaccines and venoms & toxins.

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Oncology peptide therapeutics

Application Notes

Synthesis of [des-Arg7]-Dyn A (1-9)-NH2 peptoid hybrid

Automated solid phase peptide synthesis (SPPS) increases reliability, efficiency, and crude purity for peptides and peptoids.



Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic Beta-hairpins
Danelius E. et al. Org. Biomol. Chem., 2016,14, 10386-10393.2016

Serum Stability and Affinity Optimization of an M2 Macrophage-Targeting Peptide (M2pep).
Ngambenjawong C. et al. Theranostics, 6(9), 1403-1414.2016

A Peptide Mimicking a Region in Proliferating Cell Nuclear Antigen Specific to Key Protein Interactions Is Cytotoxic to Breast Cancer.
Smith S. J. et al. Molecular Pharmacology, 87(2), 263-276. 2015

Targeted therapy of colorectal neoplasia with rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles.
Khondee S. et al. Journal of Controlled Release: Official Journal of the Controlled Release Society, 199, 114-121.2015

Targeted bioimaging and photodynamic therapy of cancer cells with an activatable red fluorescent bioprobe.
Hu Fang et al. Analytical chemistry 86.15 (2014): 7987-7995.2014

Simultaneous Inhibition of Key Growth Pathways in Melanoma Cells and Tumor Regression by a Designed Bidentate Constrained Helical Peptide
Dhar A. et al. Biopolymers. 2014 Jul;102(4):344-58.2014

Molecular specialization of breast vasculature: a breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature.
Essler M. & Rouslahti E. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2252-7.2002

Chemotherapy induces adaptive drug resistance and metastatic potentials via phenotypic CXCR4-expressing cell state transition in ovarian cancer
Lee H.H. et al. PLoS One. 2017 Feb 14;12(2):e0171044.2017

VHH characterization. Comparison of recombinant with chemically synthesized anti‐HER2 VHH
Lucie Hartmann, et al. Protein Science2019

Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-coil Domain Truncations
Brown, Z.Z, et al.  J. Org. Chem. Just accepted 2019

Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses
Kodalivand, N. et al. Journal of controled release2019

Identification of Key Amino Acids in the Anti-Cancer Activity of CDT Peptide Analogs
Jaylen E. Taylor McNair Scholars Research Journal2020