Gyrolab references

Find scientific references by application. 

Long-acting protein drugs for the treatment of ocular diseases
Joy Ghosh et al. Nature Communications 8, Article number: 14837 (2017). 2017  

Reagent-free LC-MS/MS-based pharmacokinetic quantification of polyhistidine-tagged therapeutic proteins
Shi, J et al. Bioanalysis. 2017 Feb;9(3):251-264. 2017  

Long-acting protein drugs for the treatment of ocular diseases
Ghost, GJ, et al. Nature communications 2017 Mar 23;8:14837. 2017  

Capillary microsampling in nonclinical safety assessment: practical sampling and bioanalysis from a CRO perspective
Coleman, D et al. Bioanalysis. 2017 May 19. doi: 10.4155/bio-2017-0032. [Epub ahead of print]. 2017  

Evaluation of a digital dispenser for direct curve dilutions in a vaccine potency Assay
Roselle, C et al. Journal of Immunological Methods. 2017  

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates
Tumey LN, et al. The AAPS Journal April 24. 2017  

Assessment of Preclinical Liver and Skeletal Muscle Biomarkers Following Clofibrate Administration in Wistar Rats
Maliver, P et al. Toxicologic Pathology 1-20. 2017  

An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration
Großhans, S. et al. Journal of Chromatography A Available online 6 December 2017. 2017  

Assessment of near-infrared fluorophores to study the biodistribution and tumor targeting of an IL13 receptor α2 antibody by fluorescence molecular tomography
Gupta, P et al. Oncotarget, 2017, Vol. 8, (No. 34), pp: 57231-57245 2017  

N-Glycan profile analysis of transferrin using a microfluidic compact disc and MALDI-MS
Quaranta, A et al. Analytical and Bioanalytical Chemistry (2016) 408:4765-4776. 2016  

Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling
Almquist, J et al. CPT Pharmacometrics Systems Pharmacology 2016 Jun;5(6):313-23 . 2016  

Platform switching from ELISA to Gyrolab™: a novel generic reagent omits the need to change critical reagents
Jordan, G et al. Bioanalysis 2016 Apr;8(8):807-14 . 2016  

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies
Avery, LB et al. mAbs 2016 May 27:1-15. [Epub ahead of print]. 2016  

Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model
Weirong, W et al. Pharmaceutical Research, 2016, 1-10 . 2016  

Quantitative analysis of hIgG1 in monkey serum by LC-MS/MS using mass spectrometric immunoassay
Lanshoeft, C et al. Bioanalysis 2016 May;8(10):1035-49. 2016  

Accelerating Regulated Bioanalysis for Biotherapeutics: Case Examples Using a Microfluidic Ligand Binding Assay Platform
Liu, R et al. The AAPS Journal, Volume 19, Issue 1, pp 82-91. 2016  

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
Zuchero, YJ, et al. Neuron 89, 70-82. 2016  

Feasibility of Singlet Analysis for Ligand Binding Assays: a Retrospective Examination of Data Generated Using the Gyrolab Platform
Clark, TH. AAPS J. 2016 Sep;18(5):1300-8. 2016  

A semi-universal assay platform to quantitate vaccines with potential applications for biotherapeutics
Roman, J et al. Bioanalysis (2016) 8(24), 2523-2535. 2016  

Antibody–drug conjugate bioanalysis using LB-LC–MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding
Wang, J et al. Bioanalysis 2016 Jul;8(13):1383-401. 2016  

Validation of an integrated series of ligand-binding assays for the quantitative determination of antibody-drug conjugates in biological matrices
Myler, H et al. Bioanalysis (2016) 8(6), 519-531. 2016  

Calculated conjugated payload from immunoassay and LC-MS intact protein analysis measurements of antibody-drug conjugate
Rago, B et al. Bioanalysis 2016 Nov;8(21):2205-2217. 2016  

Evaluation of highly sensitive immunoassay technologies for quantitative measurements of sub-pg/mL levels of cytokines in human serum
Yeung, D et al. Journal of Immunological Methods 2016 Oct;437:53-63. 2016  

Evaluation of Multiple Immunoassay Technology Platforms to Select the Anti-Drug Antibody Assay Exhibiting the Most Appropriate Drug and Target Tolerance
Collet-Brose, J et al. Journal of Immunology Research. 2016  

Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies
Partridge, M A et al. Journal of Immunology Research . 2016  

Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development
Tibbitts, J et al. mAbs. 2015  

Domain antibody downstream process optimization: High-throughput strategy and analytical methods
Welsh, J P et al. Engineering in Life Sciences, DOI: 10.1002/elsc.201400255. 2015  

Development of an acidic/neutral antibody flow-through polishing step using salt-tolerant anion exchange chromatography
Kang, Y et al. Pharm. Bioprocess. (2015) 3(8), 477-487. 2015  

Automation of ELISAs & evaluation of emerging technologies for high-throughput quantitation of protein impurities
Cai, H et al. Pharm. Bioprocess. (2015) 3(7), 427-441. 2015  

Rapid Process Development Enabled by Automated, Single Use High Throughput Technologies
Ramsubramaniam, N. 2015 Annual Meeting of the Society for Industrial Microbiology & Biotechnology, Session 22: Fermentation/Cell Culture: Biologics: Delivering Innovation to Industry and Patients Alike. 2015  

Developability of Biotherapeutics
Hartmann, S et al. books.google.com. 2015  

16th Annual Land O'Lakes Bioanalytical Conference - Conference Report
Burns, EC et al. Bioanalysis Vol. 7, No. 21, Pages 2731-2734. 2015  

High-throughput screening and automation approaches for the development of recombinant therapeutic proteins
Keil, G. Pharm. Bioprocess. (2015) 3(5), 371-380. 2015  

Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: Relevance for human safety
Ryan, P C et al. Toxicology and Applied Pharmacology 279 (2014) 230–239. 2015  

The 3rd China Bioanalysis Forum annual meeting
Tang, D et al. Bioanalysis (Epub ahead of print). 2015  

7 Best Practices in Assessment of Developability of Biopharmaceutical Candidates
Hartmann, S et al. Developability of Biotherapeutics: Computational . 2015  

Serum sample stability in ligand-binding assays: challenges in assessments of long-term, bench-top and multiple freeze-thaw
Cris Macaraeg et al. Bioanalysis (2015) 7(11), 1361-1370. 2015  

Miniaturized Blood Sampling Techniques to Benefit Reduction in Mice and Refinement in Nonhuman Primates: Applications to Bioanalysis in Toxicity Studies with Antibody-Drug Conjugates
Caron, A et al. Journal of the American Association for Laboratory Animal Science, Vol 54, No 2 March 2015 Pages 145-152. 2015  

Indirect assessment of neutralizing anti-drug antibodies utilizing pharmacokinetic assay data
Vettermann, C et al. Journal of Immunological Methods S0022-1759(15)30076-4. 2015  

Studies of Nontarget-Mediated Distribution of Human Full-Length IgG1 Antibody and Its FAb Fragment in Cardiovascular and Metabolic-Related Tissues
Davidsson, P et al. Journal of Pharmaceutical Sciences, Vol. 104, Volume 104, Issue 5, pages 1825-1831, May 2015 . 2015  

Emerging Technologies to Increase Ligand Binding Assay Sensitivity
Fischer, SK et al. The AAPS Journal, Vol. 17, No. 1 . 2015  

Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates
Saad, OM et al. Bioanalysis (2015) 7(13). 2015  

Antibody-drug conjugates nonclinical support: from early to late nonclinical bioanalysis using ligand-binding assays
Kumar, S et al. Bioanalysis (2015) 7(13), 1605-1617. 2015  

Characterization of Human Organ Donors Testing Positive for Type 1 Diabetes-Associated Autoantibodies
Wiberg, A et al. Clinical Experimental Immunology 2015 Dec;182(3):278-88. 2015  

Development of an Immunoassay with Gyrolab Workstation for the Quantification of sAXL in Mouse and Human Plasma
Lu, X. et al. 2015 AAPS NBC. 2015  

Delivering rhFGF-18 via a bilayer collagen membrane to enhance microfracture treatment of chondral defects in a large animal model
Howard, D et al. Journal of Orthopaedic Research, Accepted 7 February 2015. 2015  

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic Beta-Cells
Shang, J et al. Molecular Endocrinology, doi: 10.1210/me.2014-1335. 2015  

M1041 - Development of an Immunogenicity Assay Format for Use in Preclinical Monkey Studies Using the Gyrolab Platform
Hammond, M. 2015 AAPS NBC. 2015  

Comparative immunogenicity assessment: a critical consideration for biosimilar development
Liu, PM et al. Bioanalysis (2015) 7(3). 2015  

M1053 - Immunogenicity Assay Development on the Gyrolab Platform: Increasing Sensitivity and Drug Tolerance
Hsieh, S. et al. 2015 AAPS NBC. 2015  

M1040 - Generic Drug Tolerant Immunogenicity Assay to Detect Rat Antibodies against Human Antibody Drugs Using the Gyrolab xP Workstation
Ehlinger, C. et al. 2015 AAPS NBC. 2015  

M1024 - Development of an Immunogenicity Assay Using Gyrolab Platform for a Therapeutic Monoclonal Antibody (Mab)
Elango, C. et al. 2015 AAPS NBC. 2015  

Immunogenicity assessment of biotherapeutic products: An overview of assays and their utility
Wadhwa, M et al. Biologicals (2015) 1-9. 2015  

Strategies to compare clinical antitherapeutic antibody data when changing assay platforms: a case study
Qui, ZJ et al. Bioanalysis (2015) 7(14) , 1775-1783. 2015  

A microfluidic approach to high throughput quantification of host cell protein impurities for bioprocess development
Heo, JH et al. Pharmaceutical Bioprocessing Vol. 2, No. 2, Pages 129-139. 2014  

Improving Efficiency and Data Reproducibility through the Use of Fully Integrated Automation in Bioanalysis of Biotherapeutics
Burns, D et al. AAPS. 2014  

Active glucagon-like peptide 1 quantitation in human plasma: A comparison of multiple ligand binding assay platforms
Fraser, S, et al. Journal of Immunological Methods, April 8. 2014  

Application of quality by design and statistical quality control concepts in immunoassays
Verch, T . Bioanalysis (2014) 6(23), 3251-3260. 2014  

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties
Faleri, A et al. The FASEB Journal Vol. 28 April 2014 1644-1653. 2014  

Assessing Effects of Freeze-Thaw on Biotinylated Macromolecules Using Gyrolabâ„¢
Liu, XF et al. J Bioanal Biomed 6: 049-051. 2014  

A Multifactorial Screening Strategy to Identify Anti-Idiotypic Reagents for Bioanalytical Support of Antibody Therapeutics.
Salimi-Moosavi, H et al. Anal Biochem 2015, Feb 1; 470:52-60. Epub 2014 Oct 27. 2014  

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties.
Faleri, A, et al. Journal of Immunological Methods, April 8. 2014  

One Mouse, One Pharmacokinetic Profile: Quantitative Whole Blood Serial Sampling for Biotherapeutics
Joyce, AP, et al. Pharm Res. 2014 Jan 24. 2014  

Evaluating Multiple Technology Platforms to Meet Challenges of Developing a Ligand Binding Assay to Support Clinical Trials Conducted in Adult or Pediatric Populations
Collet, J et al. AAPS. 2014  

A breakthrough novel method to resolve the drug and target interference problem in immunogenicity assays
Zoghbi, J. J Immunol Methods. 2015 Nov;426:62-9. 2014  

A Multifactorial Screening Strategy to Identify Anti-Idiotypic Reagents for Bioanalytical Support of Antibody Therapeutics
Salimi-Moosavi, H et al. Analytical Biochemistry S0003-2697(14)00452-7. 2014  

Multiparameter Comparison of PK Immunoassay for a Therapeutic Monoclonal Antibody Implemented on Four Different Platforms
Kozhich, A et al. AAPS. 2014  

Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis
Chakravarthy, K et al. BMC Musculoskeletal Disorders 2014, 15:409. 2014  

Validation of a microfluidic platform to measure total therapeutic antibodies and incurred sample reanalysis performance
Magana, I et al. Bioanalysis (2014) 6(19), 2623-2633. 2014  

Abstract 4293: Whole-body bio-distribution of anti-5T4-mcMMAF (anti-5T4-ADC) using fluorescence molecular tomography (FMT) imaging in a non-small cell lung cancer mice model.
Giddabasappa, A et al. Cancer Res October 1, 74; 4293. 2014  

Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis
Chakravarthy, K et al. BMC Musculoskeletal Disorders 2014, 15:409. 2014  

Challenges in selectivity, specificity and quantitation range of ligand-binding assays: case studies using a microfluidics platform
Yang, T-Y et al. Bioanalysis (2014) 6(8), 1049-1057. 2014  

Biomarker Quantitation on GyroLab Platform: A Case for a Two Step Assay
Dysinger, M et al. AAPS, Poster. 2014  

A Gyros Platform Advanced Immunoassay Validation of E-Selectin as a Safety Biomarker for Vascular Injury in Rat
Cameron, M. J. et al. AAPS, Poster. 2014  

Urine Urea Impacts the Accuracy of Soluble Vascular Cell Adhesion Molecule 1 (sVCAM-1) Urinary Immunoassay
Shen,C et al. AAPS, Poster. 2014  

Binding of Autoantibodies Varies Widely between beta-1-Adrenergic Receptor (beta1-AR) Constructs
Nazneen, B . AAPS. 2014  

The Gyrolabâ„¢ immunoassay system: a platform for automated bioanalysis and rapid sample turnaround
Fraley, KJ et al. Bioanalysis 2013 Jul;5(14):1765-74. 2013  

Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics
Ishino, T et al. J. Biol. Chem., Jun 2013; 288: 16529 - 16537. 2013  

Glycosylation Profiling of Therapeutic Antibodies in Serum Samples Using a Microfluidic CD Platform and MALDI-MS
Thuy, TT et al. J. Am. Soc. Mass Spectrom (2013). 2013  

Bioanalytical platform comparison using a generic human IgG PK assay format
Leary, BA et al. J Immunol Methods. 2013 Aug 29. pii: S0022-1759(13)00234-2. 2013  

Automating bioanalytical sample analysis through enhanced system integration
Patel, V et al. Bioanalysis 2013 Jul;5(13):1649-59. 2013  

A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study
Park, W et al. Ann Rheum Dis 2013;0:1-8. 2013  

Rapid development of multiple 'fit-for-purpose' assays on an automatic microfluidic system using a streamlined process in support of early biotherapeutics discovery programs
Liu, R et al. Bioanalysis 2013 Jul;5(14):1751-63. 2013  

An extended range generic immunoassay for total human therapeutic antibodies in preclinical pharmacokinetic studies
Hall, CM et al. J Immunol Methods. 2013 Jul 31;393(1-2):70-3. 2013  

Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity
Sampei, Z et al. PLoS ONE 8(2): e57479. 2013  

Analytical assay platforms for soluble target engagement biomarkers: old favorites and emerging technologies
Goodman, J et al. Bioanalysis (2013) 5(23), 2919-2931. 2013  

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β
Henderson, SJ et al. Brain (2013) doi: 10.1093/brain/awt308 . 2013  

Capillary microsampling and analysis of 4-μl blood, plasma and serum samples to determine human a-synuclein elimination rate in mice
Jonsson, O et al. Bioanalysis 2013, 5(5) 449-462. 2013  

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
Piper, E et al. Eur Respir J. 2013 February; 41(2): 330-338. 2013  

Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses
Spensieri, F et al. PNAS, Aug 2013; 110: 14330 - 14335. 2013  

AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
Georgievska, B et al. J Neurochem. 2013 May;125(3):446-56. 2013  

Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis
Gonzales, AJ et al. Vet Dermatol 2013, 24: 48-e12. 2013  

Rapid affinity measurement of protein-protein interactions in a microfluidic platform.
Salimi-Moosavi, H et al. Anal Biochem. 2012 Jul 15;426(2):134-41. . 2012  

Discrimination between glycosylation patterns of therapeutic antibodies using a microfluidic platform, MALDI-MS and multivariate statistics
Thuy, TT et al. J Pharm Biomed Anal. 2012 Nov;70:47-52. 2012  

Validation of a gyrolabâ„¢ assay for quantification of rituximab in human serum
Liu, XF et al. Journal of Pharmacological and Toxicological Methods. 2012  

Implementation of a universal analytical method in early-stage development of human antibody therapeutics: application to pharmacokinetic assessment for candidate selection
Shih, J et al. Bioanalysis 2012, 4(19) 2357-2365. 2012  

Validation of a Gyrolabâ„¢ assay for quantification of rituximab in human serum
Liu, XF et al. J Pharmacol Toxicol Methods, 2012, 65 (3) 107-114. 2012  

Development and validation of an alpha fetoprotein immunoassay using Gyros technology.
Given, AM et al. J Pharm Biomed Anal. 2012 May;64-65:8-15. 2012  

Development of residual host cell protein assays for recombinant microbial biopharmaceuticals
Peiris, KJ et al. 5th Annual European Gyrolab Seminar, Siena, Italy. 2011  

The Manufacture of mAbs - A Comparison of Performance and Process Time between Traditional and Ready-to-Use Disposable Systems
Eibl, R et al. Single-Use Technology in Biopharmaceutical Manufacture, Published Online: 19 Jan 2011 DOI: 10.1002/9780470909997.ch28. 2011  

Application Report 206: Single-system solution for quantification of monoclonal IgG and host cell proteins (HCP)
Inganäs, M. Gyros Application Report. 2011  

High-throughput profiling of N-linked oligosaccharides in therapeutic antibodies using a microfluidic CD platform and MALDI-MS
Thuy, TT et al. Anal Bioanal Chem (2011) 399:1601-1611. 2011  

Automated immunoassay equipment platforms for analytical support of pharmaceutical and biopharmaceutical development
Allinson, J L . Bioanalysis (2011) 3(24), 2803-2816. 2011  

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo
Ni, YG et al. J Lipid Res 2011, 52(1) 78-86. 2011  

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
Wang, W et al. Mol Immunol 2011, 48 860-866, doi:10.1016/j.molimm.2010.12.009. 2011  

Application Report 205: Quantification of antigen-specific antibodies in serum
Inganäs, M. Gyros Application Report. 2011  

Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells
Gustafsson, K et al. BMC Immunol. 2011 12:3. doi: 10.1186/1471-2172-12-3. 2011  

Application Report 204: Insulin quantification:save sample and increase efficiency
Inganäs, M. Gyros Application Report. 2011  

Application Report 207: Miniaturizing immunoassays for improved performance
Inganäs, M. Gyros Application Report. 2011  

Development of an automated ADA immunoassay with integrated acid dissociation and neutralization
Eckersten, A et al. Poster. 2011  

Application of the Gyrolab platform to ligand-binding assays: a user's perspective
Mora, J et al. Bioanalysis 2010, 2 (10) 1711-1715. 2010  

Addressing Ligand Binding Assay Deficiencies
Brady, K. Genetic Engineering & biotechnology News 2009, 29 (14) 33. 2010  

Parallel sample preparation of proteins, from crude samples to crystals ready for MALDI-MS, in an integrated microfluidic system
Thuy, TT et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2010 Oct 15;878(28):2803-10. 2010  

Gyrolab Demonstrated Shorter Assay Time and Broader Dynamic Range Compared to a Plate Based ELISA with a Generic Human IgG Assay in Rat Serum
Mallozzi, C & Kavosi, M. Inaugural North American Gyrolab Seminar. 2010  

High Throughput Ligand Binding Assay for Therapeutic Antibodies and Biomarkers Using Gyros Microfluidic Instrument
Salimi-Moosavi, H. NBC Symposium: Advantages of Non-Traditional Technologies for Ligand Binding Assay Development, 2010. 2010  

New analytical technologies for biological discovery
Shen, H-W & Yu, A-M. Bioanalysis 2010, 2(2), 181-184. 2010  

Application of miniaturized immunoassays to discovery pharmacokinetic bioanalysis
Roman, J et al. J Pharmacological Toxicological Methods, online December 2010. 2010  

Phase I, Double-blind, Randomized, Placebo-controlled, Dose-escalation Study of NI-0401 (a Fully Human Anti-CD3 Monoclonal Antibody) in Patients with Moderate to Severe Active Crohn̥s Disease
van der Woude, C et al. Inflamm Bowel Dis. 2010, 16(10) 1708-16. 2010  

A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma
Singh, D et al. BMC Pulm Med. 2010, 8 10:3. 2010  

An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males
Oh, C K et al. Brit J Pharmacol 2010, 69 (6) 645-655. 2010  

Gyrolab in a GxP environment: the Merck Serono experience
Crosasso, C et al. Poster. 2010  

Production of Non-fucosylated Antibodies by Co-Expression of Heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase
von Horsten, H. Glycobiology. 2010, 20 (12) 1607-18. 2010  

Evaluation of a Single-Use Bioreactor for the Fed-Batch Production of a Monoclonal Antibody
Cameau, E et al. BioPharm International Supplements, Nov. 2010. 2010  

Validation of a ligand binding assay
Eckersten, A et al. 4th Annual European Gyrolab Seminar. 2010  

Evaluation of in vitro and in vivo tau phosphorylation using the Gyros immunoassay platform
Thomas, AK et al. Society for neurosciences meeting November 2010. 2010  

Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning
Sadeghi, B et al. Clin Dev Immunol. 2010, 142943. doi: 10.1155/2010/142943. Epub 2010 Dec 21. 2010  

Resolvin E1 reduces proinflammatory markers in human pancreatic islets in vitro
Lund, T et al. Exp Clin Endocrinol Diabetes. 2010, 118(4) 237-44. 2010  

Evaluation of Tau Phosphorylation using a Non-Traditional Immunoassay Platform
Boyer, S et al. 4th Annual European Gyrolab Seminar. 2010  

New analytical technologies: Pharmaceutical applications to proteins and antibodies. An industry perspective
Colombo, L et al. National meeting on medicinal chemistry (NMMC), Abano Terme, Italy, Book of abstracts, p39-40, October 2010. 2010  

Minimising Volume, Maximising Returns
Hannam, S et al. European Pharmaceutical Review, Discovery Technology, Spring 2010. 2010  

Immunogenicity monitoring during preclinical development of Nanobodies¨: comparing assay formats and species matrices
Poelmans, S et al. AAPS. 2010  

A novel strategy to reduce the immunogenicity of biological therapies
Somerfield, J et al. J Immunology 2010, 185 (1) 763-768. 2010  

Utility of the Gyros Gyrolab in Research and DMPK - an automated ligand binding assay platform
Brady, K. PPT presentation. 2010  

Gyrolab in a validated environment
Kelley, M. Gyrolab Seminar, 2009. 2009  

Design and testing of a microfluidic biochip for cytokine enzyme-linked immunosorbent assay
He, H et al. Biomicrofluidics. 2009, 3 (2) 22401. 2009  

Increased sample volume improves ability to quantify cytokines in Gyrolab Bioaffy 1000
Clizbe, D et al. Poster. 2009  

Analyses of AKT and PDGF receptor expression and activation in human tumors
Paulsen, J. PhD thesis ISBN: 978-91-7409-504-3. 2009  

Gyrolab applications in industrial monoclonal antibody development
Wallby, E et al. Poster. 2009  

Quantification of MabSelect SuRe ligand in presence of excess amounts of IgG on Gyrolab
Lehtonen, P & Inganas, M. Poster. 2009  

Formation of Composite Endothelial Cell-Mesenchymal Stem Cell Islets A Novel Approach to Promote Islet Revascularization
Johansson, U et al. Diabetes 2008, 57 (9) 2393-2401. 2008  

Regulatory T cell-associated activity in photopheresis-induced immune tolerance in recent onset type 1 diabetes children
Jonson, C-O. Clin Exp Immunol. 2008, 153 (2) 174-181. 2008  

Effects of Alcohol Consumption on the Allergen-Specific Immune Response in Mice
Linneberg, A et al. Alcoholism: Clin and Expl Res. 2008, 32 (3) 553-557. 2008  

Use of Gyrolab in Biotechnology Process Development
Bishop, E . Gyrolab Seminar. 2008  

Improved analytical tools for quantification of monoclonal IgG and host cell proteins during biopharmaceutical process development
Lehtonen, P et al. WCBP. 2007  

Parallel nanoliter microfluidic analysis system
Andersson, P et al. Anal Chem. 2007, 79 (11) 4022-4030. 2007  

CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden
Mayans, S et al. BMC Medical Genetics 2007, 8:3. 2007  

Automated protein quantification in bioprocess development and pharmacokinetic studies: Improving assay performance
Osterlund, K et al. Merck Technology Symposium. 2007  

Simultaneous Multiple Immunoassays in a Compact Disc-Shaped Microfluidic Device Based on Centrifugal Force
Honda, N et al. Clin Chem 2005, 51 (10) 1955-1961. 2005  

The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune reponse
Rivera, E et al. Vaccine 2005, 23 (46-47) 5411-5419. 2005  

Determining cytokine levels from small sample volumes in vaccine studies using Gyrolab Bioaffy
Inganäs, M et al. 12th International Congress of Immunology and 4th Annual Conference of FOCIS Montreal, Canada, July 18-23, 2004. 2004