Gyros Protein Technologies

Recorded Webinar from May 26, 2020

SPPS tips for success: Strategies for minimizing side-reactions

Synthetic peptides are used in a variety of different applications ranging from clinical therapeutics and personalized medicines, to immunoassay screening, antibody production and vaccine design. As peptide chemists strive to achieve new methods and techniques for solid phase peptide synthesis (SPPS), strategies must also be implemented to help reduce the occurrence of unwanted side reactions that inevitability take place during the chemical synthesis process.

This session in the “SPPS Tips for Success” webinar series will focus on side reactions that occur during SPPS and what strategies can be employed to reduce or eliminate these from occurring. Aspartimide formation, racemization, or oxidation can be the thorn in the side of any peptide synthesis project, but how can we identify unwanted side products and what can be done to limit their formation? In this webinar we will discuss preventative measures that can be used depending upon which amino acid residues may be present in the peptide sequence. This session will also cover some side reactions that may occur during cleavage and purification. Whether you are a new or experienced peptide chemist, this webinar will no doubt prove invaluable when designing your next peptide synthesis strategy!

Learning Objectives:

  • Understand how to identify unwanted side products that can form during SPPS.
  • Learn how to implement proactive measures to reduce the risk of side reactions occurring.
  • Understand which residues and sequence motifs may be prone to side reactions or degradation.

Lukasz Frankiewicz PhD
Senior Product Specialist
Gyros Protein Technologies


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