Gyros Protein Technologies


Determination of viral titer and host cell proteins to support viral vector production in gene therapy using an automated, miniaturized immunoassay


The rapid development of gene therapy treatments has led to a great demand for assays with quick turnaround times to
support optimization of the production of viral vectors including those based on rAAV (recombinant adeno-associated
virus) and the lentiviruses, HIV-1 (human immunodeficiency virus 1) and EIA (equine infectious anemia).

Here we report the performance of three assays run on Gyrolab® system that can be used to monitor the preparation
and purity of viral vectors:

  • Transfer and optimization of a Progen AAV titer ELISA kit to Gyrolab system
  • Lentivirus vector titer analysis by quantitating the p24 viral capsid protein using Gyrolab p24 Kit
  • Determination of host cell protein (HCP) impurities from the human embryonic kidney cell line (HEK 293)

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