Riding new Tides: Synthesis of oligonucleotides on PurePep® Chorus

In the field of drug discovery, the boundary between biopolymers such as proteins, peptides, and oligonucleotides continues to fade. Therefore, quick access to these molecules through flexible synthesis platforms is crucial for competitive drug development.
This application note highlights the successful synthesis of short oligonucleotides (18-24 bases) on the PurePep® Chorus, showcasing its versatility beyond peptide synthesis.

Results at a glance

• Expand the synthesis capabilities from peptides to
  oligonucleotides on the PurePep Chorus
• Efficiently obtain high-quality short oligonucleotide
  sequences with DMT-on purification
• Apply sulfurization in the automated synthesis process to
  expand the chemical flexibility