SYMPHONY® X 

Maximum flexibility for research, optimization and production

With Ultra PurePep™ Pathway

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  • Ultra PurePep™ Pathway "inside"- Pure reliability
  • Fully independent channels
  • Infrared heating
  • Real-time UV monitoring
  • Preactivation
  • Special reagent additions
  • Automated cleavage
Ultra PurePep Pathway “inside”
The proprietary ultra PurePep Pathway is enhanced with a dedicated microfluidic matrix valve block pathway for each reaction vessel resulting in pure peptides. Nitrogen and vacuum move all fluids through the system, the membranes are resistant to harsh chemicals, there is zero dead volumes, no cross-contamination, and best-in-class performance that lasts for years. Other systems use off-the-shelf valves that leak or corrode, result in cross-contamination, and quickly fail when exposed to harsh peptide synthesis chemicals. With the ultra PurePep Pathway inside Symphony® X, all fluid deliveries are verified via optical sensors and you have reliable peptide purity every time.
Fully independent channels
Symphony X is the world’s first peptide synthesizer with fully independent channels. This means you can run different sequences, scales and protocols on multiple reactors all at the same time. Start, Stop or Pause reactors whenever you wish! It’s like having 24 synthesizers in one.
Infrared (IR) heating
Efficient heating, reaching set temperature in minimal time. It is also fully-compatible with vortex mixing, so you can be sure you have an even temperature profile. Other heating systems use nitrogen mixing, which may result in hot and cold spots and effect the consistency of your chemistry.
Real-time UV monitoring
Minimize trial-and-error when synthesizing difficult peptides using the Intellisynth® real-time UV monitoring on the Symphony X instrument. What makes our UV monitoring different? Other systems just monitor the waste stream.  We monitor your reaction solution while it’s mixing – that’s why we’re the only ones who can control the deprotection reaction times, not just the number of repetitions. Real-time UV monitoring ensures that reactions are completed efficiently and no excess reagent is wasted.
Preactivation
Now you can preactivate on multiple reactors in parallel. Perfect for sterically hindered amino acid additions! Optimize your DIC/HOBt chemistry on Symphony X and go straight to scale-up.
Special reagent additions
At last! Add expensive special reagents to any reactor without priming or wasting a drop using Single-Shot™ deliveries! Save money with no manual intervention required! Symphony X comes with up to 40 amino acid positions to accommodate any chemistry.
Automated cleavage
Symphony X includes the ability to do automated, fully customizable cleavage without the need for an additional module. Choose to cleave immediately (Fmoc only), at the end of a synthesis, or at a specified date and time. Cleaved peptides are collected in convenient 50 mL centrifuge vials. All Protein Technologies’ synthesizers are built with robust TFA-resistant materials, so you can cleave for years on the instruments without worry. Not interested in cleavage? You have the flexibility to use the Symphony X collection positions as additional amino acid positions.

Specifications

Number of reaction vessels
24 (12 with pre-activation option), no resin loader required
Synthesis scale range
0.005 – 24 mmol (up to ~2 g of resin per RV)
Reaction vessel volume
Plastic, disposable:10 mL, 45 mL, Borosilicate glass: 10 mL, 40 mL
Number of solvent positions/sizes
1 primary solvent position, 20 L capacity
7 user-defined solvent positions, 0.5 L - 4 L capacities
Number of amino acid positions
Up to 40 amino acid positions
10 mL, 120 mL and 400 mL bottles
Chemistries supported
Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA
Activation
In situ HBTU, HATU, HCTU, TBTU, PyBOP, PyOxim, DIC/OxymaPure, DIC/HOBt, DIC/Oxyma-B and others
Throughput
User defined
Fluid measurement technique
Fixed loop measurement with optical sensors
Fluid transfer method
Positive pressure with nitrogen; top down delivery
Agitation method
Nitrogen bubbling and/or vortex mixing can be adjustable and programmable
Cleavage
Automated on-board cleavage, separate fluid path and vent
Waste container
One 20 L container with over-flow sensor
Control interface
Proprietary Symphony X control software, internal CPU and touchscreen monitor included
Reporting
Real-time log of each instrument function, print to file or printer. Printable .pdf file for each method created.
Start-up kit
20 pre-filled AA bottles at both 5 mmol and 20 mmol sizes with 100 g coupling agent and separate test peptide AA’s in 0.5 mmol scale, base and deprotectant, disposable reaction vessels (30 x 10 mL and 2 x 45 mL), Rink Amide Resin (0.1 mmol scale), Fmoc-L-Gly Wang Resin (0.1 mmol scale). (Cat#: SYMX-STARTKIT)
Power
115 V/60 Hz or 230 V/50 Hz
Dimensions (W x D x H)
45” x 29” x 66” (114 cm x 74 cm x 168 cm)
Weight
Approximately 550 lbs. (250 kg)
Warranty
One year, parts and labor
OPTIONAL - Heating
Infrared (IR) heating (Cat#: SYMX-IR-OPT)
OPTIONAL - UV Monitoring
Intellisynth Real-time UV Monitoring and feedback control system and software (Cat#: SYMX UV OPT)
OPTIONAL - Software
E-mail-Text Message Status Reporting (Cat#: SYMX-TXT-EML-RP)

PurePep Reagents

Reagents

Resins

Coupling Agents

 

Your peptide synthesis needs are important to us. If you would like custom packaging, other special handling conditions, or a quote please send us your request here peptides@gyrosproteintech.com

Accessories

All instrument accessories and spare parts are available to order in our online shop, you can open the Symphony X accessories here