Peptide Synthesis Applications

Gain insight into how Protein Technologies' platforms have been applied in research and development related to biomaterials, drug delivery, peptide therapeutics, vaccines and venoms & toxins.

View recorded webinar: Chemical, Computational, and Instrumental Tools for Challenging Peptide Syntheses. >>
Speaker: Michael S Kay, MD/PhD, Professor. Biochemistry, University of Utah

Review articles on GEN BioPerspectives published in December 2016 >>

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Multifunctional thermoresponsive designer peptide hydrogels.
De Leon-Rodriguez L.M. et al. Acta Biomaterialia Volume 47, 1 January 2017, Pages 40–49.2016

Biocompatibility and Characterization of a Peptide Amphiphile Hydrogel for Applications in Peripheral Nerve Regeneration.
Black K.A. et al. Tissue Engineering. Part A, 21(7-8), 1333-1342. 2015

Protease degradable electrospun fibrous hydrogels.
Wade R. J. et al.  Nature Communications, 6, 6639. 2015

A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel.
Frohm B. et al.  Soft matter 11.2 (2015): 414-421.2015

Photoresponsive elastic properties of azobenzene-containing poly(ethylene-glycol)-based hydrogels.
Rosales A. M. et al. Biomacromolecules, 16(3), 798-806.2015

Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition.
Sridhar B. V. et al. Advanced Healthcare Materials, 4(5), 702-713.2015

Design of thiol-ene photoclick hydrogels using facile techniques for cell culture applications
Sawicki L. A. et al. Biomaterials Science, 2(11), 1612-1626.2014

Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.
Kuo C.-H. et al. Journal of Materials Chemistry. B, Materials for Biology and Medicine, 2(46), 8142-8153.2014

Design and characterization of a synthetically accessible, photodegradable hydrogel for user-directed formation of neural networks.
McKinnon D. D. et al. Biomacromolecules 15.7 (2014): 2808-2816.2014

A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration.
Singh S. P. et al. Biomaterials Science, 2(7), 1024-1034.2014

Mechanical memory and dosing influence stem cell fate.
Yang C.  Nature Materials, 13(6), 645-652.2014

Measuring cellular forces using bis-aliphatic hydrazone crosslinked stress-relaxing hydrogels.
McKinnon D.D. et al. Soft Matter, 10(46), 9230-9236.2014

Origins of Structural Flexibility in Protein-Based Supramolecular Polymers Revealed by DEER Spectroscopy.
Tavenor N. A. et al. The Journal of Physical Chemistry. B, 118(33), 9881-9889.2014

The Role of Valvular Endothelial Cell Paracrine Signaling and Matrix Elasticity on Valvular Interstitial Cell Activation.
Gould S.T. et al. Biomaterials, 35(11), 3596-3606.2014

Secondary Photocrosslinking of Injectable Shear‐Thinning Dock‐and‐Lock Hydrogels
Lu H.D. et al.  Advanced healthcare materials 2.7 (2013): 1028-1036.2013

Diels–Alder mediated controlled release from a poly (ethylene glycol) based hydrogel.
Koehler K.C. et al. Biomacromolecules 14.2 (2013): 538-547.2013

Role of Cell-Matrix Interactions on VIC Phenotype and Tissue Deposition in 3D PEG Hydrogels.
Gould S.T. and Anseth K.S. Journal of Tissue Engineering and Regenerative Medicine, 10.1002/term.1836.2013

Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate.
Leight J.L. et al. Biomaterials, 34(30), 7344–7352.2013

Three-dimensional hMSC Motility within Peptide-Functionalized PEG-Based Hydrogel of Varying Adhesivity and Crosslinking Density.
Kyburz K.A. & Anseth K.S.  Acta Biomaterialia, 9(5), 6381–6392.2013

Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly (ethylene glycol)-block-polylactide.
Chen W.L. et al. Biomaterials. 2014 Feb;35(5):1686-95.2014

Phosphorylation-dependent mineral-type specificity for apatite-binding peptide sequences
Addison W.N. et al. Biomaterials. 2010 Dec;31(36):9422-30.2010

The adsorption of preferential binding peptides to apatite-based materials.
Segvich S.J. et al. Biomaterials Volume 30, Issue 7, March 2009, Pages 1287–1298.2009

High In Vitro Antibacterial Activity of Pac-525 against Porphyromonas gingivalis Biofilms Cultured on Titanium
Li J. et al BioMed Research International Volume 2015 (2015), Article ID 909870.2015

Self-sorting heterodimeric coiled coil peptides with defined and tuneable self-assembly properties.
Aronsson C. et al. Sci Rep. 2015; 5: 14063.2015

Anchoring a Cytoactive Factor in a Wound Bed Promotes Healing.
Chattopadhyay S. et al. J Tissue Eng Regen Med. 2016 Dec;10(12):1012-1020.2014

A photoclickable peptide microarray platform for facile and rapid screening of 3-D tissue microenvironments
Sharma al. Biomaterials, Volume 143, October 2017, Pages 17-28.2017

Rapid Bioorthogonal Chemistry Enables in Situ Modulation of the Stem Cell Behavior in 3D without External Triggers
Hao Y. et al. ACS Appl. Mater. Interfaces, 2018, 10 (31), pp 26016–26027.2018